ID A0A075K9P1_9FIRM Unreviewed; 367 AA.
AC A0A075K9P1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Thiazole biosynthesis protein ThiH {ECO:0000313|EMBL:AIF50859.1};
GN ORFNames=UFO1_1304 {ECO:0000313|EMBL:AIF50859.1};
OS Pelosinus sp. UFO1.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC Pelosinus.
OX NCBI_TaxID=484770 {ECO:0000313|EMBL:AIF50859.1, ECO:0000313|Proteomes:UP000027983};
RN [1] {ECO:0000313|EMBL:AIF50859.1, ECO:0000313|Proteomes:UP000027983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UFO1 {ECO:0000313|EMBL:AIF50859.1};
RX PubMed=25189589;
RA Brown S.D., Utturkar S.M., Magnuson T.S., Ray A.E., Poole F.L.,
RA Lancaster W.A., Thorgersen M.P., Adams M.W., Elias D.A.;
RT "Complete Genome Sequence of Pelosinus sp. Strain UFO1 Assembled Using
RT Single-Molecule Real-Time DNA Sequencing Technology.";
RL Genome Announc. 2:e00881-14(2014).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP008852; AIF50859.1; -; Genomic_DNA.
DR RefSeq; WP_038669340.1; NZ_CP008852.1.
DR AlphaFoldDB; A0A075K9P1; -.
DR STRING; 484770.UFO1_1304; -.
DR KEGG; puf:UFO1_1304; -.
DR eggNOG; COG0502; Bacteria.
DR HOGENOM; CLU_046249_1_0_9; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000027983; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000027983};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 67..274
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 367 AA; 41388 MW; CE7D4B46E39CB26F CRC64;
MSFYDEYWQY AKGNIEEVFQ NTTSEDVVKI LGKERLTAKD FLALLSPKAE EHLESMAQKA
NQLTVQNFGR VILLYTPMYL SDYCTNQCTY CGFNITNTFT RKQLTMEEVE KEAKNIAASG
IQHILILTGD APVRAGVSYM EDCVQILKNY FSSIAIEVYA LTKEEYAKLG EAGVESMTMY
QETYNPIIYD KLHVKGPKKD YHFRLDAPER ACQAGLRSVN IGALLGLDDW RRDGFFTGLH
ANYLQNKYPD VEVSISLPRI RPTMGACETG SSVNDKNMVQ FMTAFRLFMP RAGMPLSTRE
SAEFRNYAIK LGITKMSAGV NTAVGGHIEV QENAGQFAVS DTRSVKEMSK AILQLGYQPV
FKDWQAI
//
