ID A0A075LKE5_9BACI Unreviewed; 280 AA.
AC A0A075LKE5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=2,5-diketo-D-gluconic acid reductase {ECO:0000313|EMBL:AIF66566.1};
GN ORFNames=GZ22_07900 {ECO:0000313|EMBL:AIF66566.1};
OS Terribacillus goriensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Terribacillus.
OX NCBI_TaxID=386490 {ECO:0000313|EMBL:AIF66566.1, ECO:0000313|Proteomes:UP000027980};
RN [1] {ECO:0000313|EMBL:AIF66566.1, ECO:0000313|Proteomes:UP000027980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP602 {ECO:0000313|EMBL:AIF66566.1,
RC ECO:0000313|Proteomes:UP000027980};
RA Wang Y., Lu P., Zhang L.;
RT "Complete genome sequence of a moderately halophilic bacterium
RT Terribacillus aidingensis MP602, isolated from Cryptomeria fortunei in
RT Tianmu mountain in China.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP008876; AIF66566.1; -; Genomic_DNA.
DR RefSeq; WP_038560728.1; NZ_CP008876.1.
DR AlphaFoldDB; A0A075LKE5; -.
DR KEGG; tap:GZ22_07900; -.
DR HOGENOM; CLU_023205_0_1_9; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000027980; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19132; AKR_AKR5D1_E1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000027980}.
FT DOMAIN 19..262
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 52
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 110
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 77
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 280 AA; 32061 MW; DE54971D601FD39A CRC64;
MHNNIPTKKL HDGTILPAVG FGTYSLKGSQ GVQAIRSAID AGYRLLDTAY NYENEATVGQ
AIKQHGISRE EILVTSKLPG RYHQHDNAIT TIQESLYRAG LDYYDLYLIH WPNPKQDHYV
EAWQTLLDAR KWGLIRSIGV CNFLPEHLER LKAETGELPV INQIELHPFF NQEKQRQYHE
ENDIVTESWS PLGRKTNLLE HPLLSEIAEN HGRTVSQIVL RWHYQLGSIA IPKSATPKRQ
VENLAIFDFE LNHADMEKIN SLTISDGRIA DQDPAVYEEF
//
