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Database: UniProt
Entry: A0A076MGV6_AMYME
LinkDB: A0A076MGV6_AMYME
Original site: A0A076MGV6_AMYME 
ID   A0A076MGV6_AMYME        Unreviewed;       538 AA.
AC   A0A076MGV6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AIJ20093.1};
GN   ORFNames=AMETH_0001 {ECO:0000313|EMBL:AIJ20093.1};
OS   Amycolatopsis methanolica 239.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Amycolatopsis.
OX   NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ20093.1, ECO:0000313|Proteomes:UP000062973};
RN   [1] {ECO:0000313|EMBL:AIJ20093.1, ECO:0000313|Proteomes:UP000062973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=239 {ECO:0000313|EMBL:AIJ20093.1,
RC   ECO:0000313|Proteomes:UP000062973};
RA   Tang B.;
RT   "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP009110; AIJ20093.1; -; Genomic_DNA.
DR   RefSeq; WP_017985947.1; NZ_CP009110.1.
DR   EnsemblBacteria; AIJ20093; AIJ20093; AMETH_0001.
DR   KEGG; amq:AMETH_0001; -.
DR   PATRIC; fig|1068978.7.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000062973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000062973};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000062973}.
FT   DOMAIN      230    358       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      442    511       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     238    245       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   538 AA;  59921 MW;  50A0248D55DEB2D7 CRC64;
     MSEHQLNLGV VWDQVVRELS DGTLSPQQRA WMRVTRPIGL LDGTALLAAP SDFAKEAIER
     ALRDPITHAL SRRLGRPVSL AVKVDTAEVT PPPPPPPAPY PSPARVETAP VAAAEAPVMP
     PKMPPLDDGM LPPLRRVRAH PAEPAKAVLP EDDGDEEVDE EGEALAAAHE IWPMFSGQPS
     AGQPYTAPAQ PETSKTRLNE KYTFDTFVIG ASNRFAHAAA FAVAEAPSRA YNPLFIWGES
     GLGKTHLLHA VGHYAQRLFP GMRVRYVSTE EFTNDFINSL RDDRKVAFQR RYRDIDILLV
     DDIQFLEGKE GTQEEFFHTF NTLHNSNKQI VVSSDRPPKR LETLEDRLRT RFEWGLITDI
     QPPELETRIA ILRKKAAQDR LAVPGDVLEF IASRVEANIR ELEGALIRVT AFASLNQQPV
     DVGLAEIVLR DLIPDSQAPE ISAPTIMATT AEFFDVTVDD LCGPGKTKAL ATARQIAMYL
     CRELTDMSLP KIGQTFGGRD HTTVMHADKK IRKEMAERRR IYDQVQELTA RIKQRARQ
//
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