ID A0A076MVK8_AMYME Unreviewed; 412 AA.
AC A0A076MVK8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Thiamin pyrophosphokinase catalytic region {ECO:0000313|EMBL:AIJ22785.1};
GN ORFNames=AMETH_2693 {ECO:0000313|EMBL:AIJ22785.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ22785.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ22785.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ22785.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009110; AIJ22785.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A076MVK8; -.
DR STRING; 1068978.AMETH_2693; -.
DR KEGG; amq:AMETH_2693; -.
DR PATRIC; fig|1068978.7.peg.2880; -.
DR eggNOG; COG4825; Bacteria.
DR HOGENOM; CLU_046690_0_0_11; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR InterPro; IPR047795; Put_SteA-like.
DR InterPro; IPR022215; SteA-like_C.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; NF040608; division_SteA; 1.
DR Pfam; PF12555; SteA-like_C; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AIJ22785.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000062973};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 363..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..404
FT /note="SteA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12555"
SQ SEQUENCE 412 AA; 43736 MW; 3C202ED1F000778C CRC64;
MHGVLRADIR LSFATIGRMK LPGLLNRNTE ALPGIVGVAR VDRRTRDLLR RVGPGDIVVL
DQIDLDRATA DALVEAEVAG VVNASPSISG RFPNLGPEIL VNAGIPLLDN VGGEVLRRIK
DGSRIRLHEG GVYVGDRHVA SGSEQTPDSV ADQMIEAKAG MSTQLEAFSA NTIEFLRRER
TLILDGVGVP EVRVPLRDRH VLVVAPGKGH AEDLKALRKY IAEHRPVLIG VDGGADTLRA
QKYQPDIIVG DPFGIDAETL KCGAEVVVPA QPDGHAPGVA RIQDLGIGAV TFPASGNPED
LALLLADAHE AGLVVTVGFQ ATLREFLDHG RSGSNPSTFL TRLKLGTRLV DGKAVAALHR
SRVSLGAVVL LVVAALVAVA VALLMSDVGG AYLDWARSTW DSFTSWVKGL FT
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