ID A0A076N460_AMYME Unreviewed; 465 AA.
AC A0A076N460;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=FAD linked oxidase domain protein {ECO:0000313|EMBL:AIJ24752.1};
GN ORFNames=AMETH_4660 {ECO:0000313|EMBL:AIJ24752.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ24752.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ24752.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ24752.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR625650-3};
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DR EMBL; CP009110; AIJ24752.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A076N460; -.
DR STRING; 1068978.AMETH_4660; -.
DR KEGG; amq:AMETH_4660; -.
DR PATRIC; fig|1068978.7.peg.5009; -.
DR eggNOG; COG0277; Bacteria.
DR HOGENOM; CLU_017779_2_3_11; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProt.
DR GO; GO:0008609; F:alkylglycerone-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.300.330; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.3450; -; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR025650; Alkyl-DHAP_Synthase.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR46568; ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL; 1.
DR PANTHER; PTHR46568:SF1; ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR625650-3};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR625650-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000062973}.
FT DOMAIN 46..225
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT BINDING 209..215
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-3"
FT SITE 260
FT /note="Important for enzyme activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-4"
SQ SEQUENCE 465 AA; 49429 MW; 225DD6BA87F82514 CRC64;
MSESELLIRQ LTAAVGAGKV LTDPAVLSAT SHDTWPVSTK WARQDQHPYR GDVVIRAGSE
ADVVAVLEVA EETGVPVTTR GLGSSVTGQP LPTRGGIVLD LSGLTGPHEV DEVDMTVTAP
AGMNGGALED ALNQAGWTMR FSPQSLYRSS VGGWLATLAT GQFSSRYGGV EDLVVGYRVV
LAGGEVAELT ASPRAAMGPD LRRVFLGSEG TLGVITRVTL KIVPLPAAQH LQTFLVPDVT
TGLAIMREQA ARGLRPSLLR LYDADEARHA MADPDFDGTV LFVGTEGEPE VAAAEMTVLT
TMATERGATE LGPEPVQAWL DRRFDFSTVE KRLDTPGGFA ETIEVAHTWR HIEGLYAAIR
KALEPLADEV LVHFSHVYPQ GTSMYVILLG QVADDAAASA RLAEIWATTM QIGLDHGAEL
SHHHGGGLAR SPYSRRSLGA AHGVLRRLKH ALDPDGLLNP GKLGL
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