ID A0A076NTM1_9CORY Unreviewed; 492 AA.
AC A0A076NTM1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:AIJ34247.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:SNV83657.1};
GN Name=cls {ECO:0000313|EMBL:SNV83657.1};
GN ORFNames=CIMIT_10450 {ECO:0000313|EMBL:AIJ34247.1}, SAMEA4535761_02147
GN {ECO:0000313|EMBL:SNV83657.1};
OS Corynebacterium imitans.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=156978 {ECO:0000313|EMBL:AIJ34247.1, ECO:0000313|Proteomes:UP000028780};
RN [1] {ECO:0000313|EMBL:AIJ34247.1, ECO:0000313|Proteomes:UP000028780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44264 {ECO:0000313|EMBL:AIJ34247.1,
RC ECO:0000313|Proteomes:UP000028780};
RA Mollmann S., Albersmeier A., Ruckert C., Tauch A.;
RT "Complete genome sequence of Corynebacterium imitans DSM 44264, isolated
RT from a five-month-old boy with suspected pharyngeal diphtheria.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SNV83657.1, ECO:0000313|Proteomes:UP000215374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13015 {ECO:0000313|EMBL:SNV83657.1,
RC ECO:0000313|Proteomes:UP000215374};
RG Pathogen Informatics;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP009211; AIJ34247.1; -; Genomic_DNA.
DR EMBL; LT906467; SNV83657.1; -; Genomic_DNA.
DR RefSeq; WP_038592548.1; NZ_LT906467.1.
DR AlphaFoldDB; A0A076NTM1; -.
DR STRING; 156978.CIMIT_10450; -.
DR KEGG; cii:CIMIT_10450; -.
DR eggNOG; COG1502; Bacteria.
DR HOGENOM; CLU_038053_1_0_11; -.
DR OrthoDB; 9762009at2; -.
DR Proteomes; UP000028780; Chromosome.
DR Proteomes; UP000215374; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000028780};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNV83657.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 219..246
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 401..432
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 492 AA; 56427 MW; 3BE25B86FEE578A4 CRC64;
MSFSFDVSYW QLVAMAIDYA IKFVMIGIVP ENRRPSSANA WLLLILLLPI VGLPLYLLMG
STLVSRRRHR IQQQATDLLN DVFTTTPDYP QGARLSPDVT SMLRLNRELT GFPAQYSRVR
RTWADYELVM QRLASLIDEA TSYVDVEIYA VAWDETTAPV FEAMERAVQR GVHVRLLFDH
IGSMKYPEFR ELKRKLTKAG IDWHLMLPLN LLRGRFRRPD LRNHRKLVVI DGRVGFLGSL
NLIDRSYLMA NHRRAGRQWV DIFIELEGPI VASMESLFAV DWYTESGELI ELKAPAPLPA
PHREDVNLMQ LLPSGPGYQT EPNLRSFNSL IHHARGHLIL CSPYFVPEES LLEAVTTACY
RGIRVDLLVG EKADQFMVNH AQSSYYQQLL EAGVHIWEFP APYILHTKFA LADPQTQEAV
GVVGSSNMDI RSFSLNYESS LFVTAGSLIR DLEKLAENYL AVSRELTPER WNRRPWYRRY
VDNVMKLTSA LQ
//
