ID A0A077DB40_LARCR Unreviewed; 154 AA.
AC A0A077DB40;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Superoxide dismutase [Cu-Zn] {ECO:0000256|RuleBase:RU000393};
DE EC=1.15.1.1 {ECO:0000256|RuleBase:RU000393};
GN Name=SOD1 {ECO:0000313|EMBL:AIL29307.1};
GN ORFNames=D5F01_LYC13505 {ECO:0000313|EMBL:KAE8287461.1};
OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Larimichthys.
OX NCBI_TaxID=215358 {ECO:0000313|EMBL:AIL29307.1};
RN [1] {ECO:0000313|EMBL:AIL29307.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EC01 {ECO:0000313|EMBL:AIL29307.1};
RC TISSUE=Liver {ECO:0000313|EMBL:AIL29307.1};
RX PubMed=25652289; DOI=10.1016/j.fsi.2015.01.032;
RA Liu H., He J., Chi C., Gu Y.;
RT "Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in
RT superoxide dismutase multigene family of Pseudosciaena crocea.";
RL Fish Shellfish Immunol. 43:491-501(2015).
RN [2] {ECO:0000313|EMBL:KAE8287461.1, ECO:0000313|Proteomes:UP000424527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMULYC20181020 {ECO:0000313|EMBL:KAE8287461.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAE8287461.1};
RA Xiao S.;
RT "Chromosome genome assembly for large yellow croaker.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Destroys radicals which are normally produced within the
CC cells and which are toxic to biological systems.
CC {ECO:0000256|ARBA:ARBA00003917, ECO:0000256|RuleBase:RU000393}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC Evidence={ECO:0000256|RuleBase:RU000393};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000256|RuleBase:RU000393};
CC Note=Binds 1 copper ion per subunit. {ECO:0000256|RuleBase:RU000393};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU000393};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU000393};
CC -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC {ECO:0000256|ARBA:ARBA00010457, ECO:0000256|RuleBase:RU000393}.
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DR EMBL; KJ908287; AIL29307.1; -; mRNA.
DR EMBL; REGW02000013; KAE8287461.1; -; Genomic_DNA.
DR RefSeq; NP_001290289.1; NM_001303360.1.
DR AlphaFoldDB; A0A077DB40; -.
DR GeneID; 104923808; -.
DR KEGG; lco:104923808; -.
DR eggNOG; KOG0441; Eukaryota.
DR OrthoDB; 3470597at2759; -.
DR Proteomes; UP000424527; Unassembled WGS sequence.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR GO; GO:0070050; P:neuron cellular homeostasis; IEA:Ensembl.
DR GO; GO:0010038; P:response to metal ion; IEA:Ensembl.
DR GO; GO:0051597; P:response to methylmercury; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 1.
DR Gene3D; 2.60.40.200; Superoxide dismutase, copper/zinc binding domain; 1.
DR InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR InterPro; IPR018152; SOD_Cu/Zn_BS.
DR InterPro; IPR001424; SOD_Cu_Zn_dom.
DR PANTHER; PTHR10003:SF103; SUPEROXIDE DISMUTASE [CU-ZN]; 1.
DR PANTHER; PTHR10003; SUPEROXIDE DISMUTASE CU-ZN -RELATED; 1.
DR Pfam; PF00080; Sod_Cu; 1.
DR PRINTS; PR00068; CUZNDISMTASE.
DR SUPFAM; SSF49329; Cu,Zn superoxide dismutase-like; 1.
DR PROSITE; PS00087; SOD_CU_ZN_1; 1.
DR PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE 2: Evidence at transcript level;
KW Copper {ECO:0000256|RuleBase:RU000393};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Metal-binding {ECO:0000256|RuleBase:RU000393};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000393};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000424527};
KW Zinc {ECO:0000256|RuleBase:RU000393}.
FT DOMAIN 15..150
FT /note="Superoxide dismutase copper/zinc binding"
FT /evidence="ECO:0000259|Pfam:PF00080"
SQ SEQUENCE 154 AA; 15794 MW; EFC0A8A4EA5667ED CRC64;
MVLKAVCVLK GDGEVGGTVF FEQENDSAPV TVTGEIKGLQ PGDHGFHVHA FGDNTNGCIS
AGPHFNPHNK NHAGPTDAER HVGDLGNVTA GADNVAKISI TDSMITLTGP ISIIGRTMVI
HEKADDLGKG GNEESLKTGN AGSRLACGVI GIAQ
//
