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Database: UniProt
Entry: A0A077FN70_9RICK
LinkDB: A0A077FN70_9RICK
Original site: A0A077FN70_9RICK 
ID   A0A077FN70_9RICK        Unreviewed;       466 AA.
AC   A0A077FN70;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AIL65980.1};
GN   ORFNames=NOVO_08270 {ECO:0000313|EMBL:AIL65980.1};
OS   Rickettsiales bacterium Ac37b.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales.
OX   NCBI_TaxID=1528098 {ECO:0000313|EMBL:AIL65980.1, ECO:0000313|Proteomes:UP000028936};
RN   [1] {ECO:0000313|EMBL:AIL65980.1, ECO:0000313|Proteomes:UP000028936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ac37b {ECO:0000313|EMBL:AIL65980.1,
RC   ECO:0000313|Proteomes:UP000028936};
RA   Felsheim R.F., Kurtti T.J., Johnson S., Labruna M.B., Munderloh U.G.;
RT   "Genome sequence of a novel Rickettsiales species cultured from
RT   Amblyomma cajennense.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP009217; AIL65980.1; -; Genomic_DNA.
DR   EnsemblBacteria; AIL65980; AIL65980; NOVO_08270.
DR   KEGG; rbt:NOVO_08270; -.
DR   KO; K02313; -.
DR   Proteomes; UP000028936; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028936};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028936}.
FT   DOMAIN      163    292       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      374    443       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     171    178       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   466 AA;  53737 MW;  9916ADC288B375AB CRC64;
     MKTASAVIYN TESANAIDTW FAIRDNLKSK YGEAIFKSWL GKLDFISFNN GQLILSAPTR
     FIKEWIYNYY SHIIQNLWHE HDKSIRQLDI IVDSGHKKSL MHPSIASTES LQNKNEDTIP
     TEEMVFSSLD KRFTFENFVV GGPNELAYAA ARATAESSKV QSESNPLFLY GGVGLGKTHL
     MHAIAWHIHE TTPWRKVVYM SAEKFMYQFV QALRNKDIMS FKEKFRSVDV LMIDDVQFIC
     GKDSTQEEFF HTFNALVDNN RQIVISCDRS PSDLEGIEER IRSRLGWGLV IDVHSTTYEL
     RLGILESKVE QLECHVPKIV LEFLASKITS NVRELEGALN KVVAHSTFVK KEINLENTQE
     ILRDLLRANE RVITIEEIQK RIAERYSLRV ADMSSSKKLR MVARPRQIAM YLSKMLTPRS
     LSEIGRKFGG KDHTTVLHAI RKIEELCNGD NEFNEEIQML MRMFQH
//
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