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Database: UniProt
Entry: A0A077JFN4_9CYAN
LinkDB: A0A077JFN4_9CYAN
Original site: A0A077JFN4_9CYAN 
ID   A0A077JFN4_9CYAN        Unreviewed;       222 AA.
AC   A0A077JFN4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=tRNA (guanosine(18)-2'-O)-methyltransferase {ECO:0000256|HAMAP-Rule:MF_02060};
DE            EC=2.1.1.34 {ECO:0000256|HAMAP-Rule:MF_02060};
DE   AltName: Full=tRNA [Gm18] methyltransferase {ECO:0000256|HAMAP-Rule:MF_02060};
GN   Name=trmH {ECO:0000256|HAMAP-Rule:MF_02060};
GN   ORFNames=ETSB_0942 {ECO:0000313|EMBL:BAP17741.1};
OS   cyanobacterium endosymbiont of Epithemia turgida isolate EtSB Lake Yunoko.
OC   Bacteria; Cyanobacteriota.
OX   NCBI_TaxID=1228987 {ECO:0000313|EMBL:BAP17741.1, ECO:0000313|Proteomes:UP000031625};
RN   [1] {ECO:0000313|EMBL:BAP17741.1, ECO:0000313|Proteomes:UP000031625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ETSB Lake Yunoko {ECO:0000313|EMBL:BAP17741.1};
RX   PubMed=25049384; DOI=10.1073/pnas.1405222111;
RA   Nakayama T., Kamikawa R., Tanifuji G., Kashiyama Y., Ohkouchi N.,
RA   Archibald J.M., Inagaki Y.;
RT   "Complete genome of a nonphotosynthetic cyanobacterium in a diatom reveals
RT   recent adaptations to an intracellular lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:11407-11412(2014).
CC   -!- FUNCTION: Catalyzes the 2'-O methylation of guanosine at position 18 in
CC       tRNA. {ECO:0000256|HAMAP-Rule:MF_02060}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-
CC         methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.34;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02060};
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000256|HAMAP-
CC       Rule:MF_02060}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_02060}.
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DR   EMBL; AP012549; BAP17741.1; -; Genomic_DNA.
DR   RefSeq; WP_044106497.1; NZ_AP012549.1.
DR   AlphaFoldDB; A0A077JFN4; -.
DR   STRING; 1228987.ETSB_0942; -.
DR   KEGG; ceo:ETSB_0942; -.
DR   HOGENOM; CLU_021322_4_2_3; -.
DR   OrthoDB; 9794400at2; -.
DR   Proteomes; UP000031625; Chromosome.
DR   GO; GO:0052665; F:tRNA (uracil-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0002938; P:tRNA guanine ribose methylation; IEA:UniProtKB-UniRule.
DR   CDD; cd18092; SpoU-like_TrmH; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   HAMAP; MF_02060; tRNA_methyltr_TrmH; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR022724; rRNA_MeTrfase_SpoU_C.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR033671; TrmH.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR43453; RRNA METHYLASE-LIKE; 1.
DR   PANTHER; PTHR43453:SF1; SPOU_METHYLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12105; SpoU_methylas_C; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW   Rule:MF_02060};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_02060};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW   Rule:MF_02060};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_02060};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP-
KW   Rule:MF_02060};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW   Rule:MF_02060}.
FT   DOMAIN          23..162
FT                   /note="tRNA/rRNA methyltransferase SpoU type"
FT                   /evidence="ECO:0000259|Pfam:PF00588"
FT   DOMAIN          166..218
FT                   /note="RNA methyltransferase SpoU/TrmH type C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12105"
FT   BINDING         122..126
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02060"
FT   BINDING         142
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02060"
FT   BINDING         151
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02060"
SQ   SEQUENCE   222 AA;  25297 MW;  48E9CDFC7901DBCF CRC64;
     MEDVIPKRYH RLKQVLNRRQ PDLTVLTEDV HKPHNLSAII RTCDAVGIFE VHSVNVKAEL
     PTFSQVSQGS EKWIFLNTHP DTRTAISYLK NQKFRVYAAH FSSKSLDYRQ IDYTKPSAII
     FGAEKWGVTK EAAQLADEHI VIPMLGMVQS LNVSVAAAVI LFEAQRQRLA ANIYDNTRLE
     SEIYDQVLFE WGYAEIARVC REQGISYPIL GENGEIKEGF SK
//
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