ID A0A077RTB4_WHEAT Unreviewed; 677 AA.
AC A0A077RTB4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Nucleobase-ascorbate transporter 12 {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRAES_3BF093200020CFD_c1 {ECO:0000313|EMBL:CDM80102.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EMBL:CDM80102.1};
RN [1] {ECO:0000313|EMBL:CDM80102.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25035497; DOI=10.1126/science.1249721;
RA Choulet F., Alberti A., Theil S., Glover N., Barbe V., Daron J.,
RA Pingault L., Sourdille P., Couloux A., Paux E., Leroy P., Mangenot S.,
RA Guilhot N., Le Gouis J., Balfourier F., Alaux M., Jamilloux V., Poulain J.,
RA Durand C., Bellec A., Gaspin C., Safar J., Dolezel J., Rogers J.,
RA Vandepoele K., Aury J.M., Mayer K., Berges H., Quesneville H., Wincker P.,
RA Feuillet C.;
RT "Structural and functional partitioning of bread wheat chromosome 3B.";
RL Science 345:1249721-1249721(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; HG670306; CDM80102.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077RTB4; -.
DR HOGENOM; CLU_017959_5_2_1; -.
DR ExpressionAtlas; A0A077RTB4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF28; NUCLEOBASE-ASCORBATE TRANSPORTER 12; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..72
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 72512 MW; 1E54A680C3573ACD CRC64;
MPAKKEGREP QPQPLSWAKR TGFQPRVSGE SSATASAPNS GQAPLPRPPG APADLESGPP
ARPNPALPPP PAAAATNAKQ QQPQPPPQQR QQQQPPAAPP ARTRRRDSEG GRPNGQPAAA
PLPQLQEEED VPERPAHVKY ELRDSPGIFP VMIYGFQHYI SMLGSIILVP LVMVPAMGGS
ADDTAAVVST VLLVSGLTTL LHTLFGTRLP LVQGPSFVYL APALAIINSP EFFGLNDNNF
KHIMKHLQGA IIIGGVFQVL LGYTGLMSLF LRLINPIVVS PTVAAVGLSF FSYGFTKLGS
CIEMGLLQLM MVIIFALYLR KIKLFGYRVF LIYAVPLGLG ITWAVAFALT ASGVYSYKGC
DANIPASNNI SAFCRKHVLK MKSCRVDTSH ALRVSPWFRF PYPLQWGTPV FNWKMGLVMC
LVSVIASVDS VGSYHASSLF VATRPPTAGI VSRGIGVEGI STVLAGLWGT GVGSATITEN
VHTIAVTKMG SRKAVGFGAI VLILLSLVGK VGAFIASIPD VMVAALLCFM WAMLCALGLS
NLRYGATGSS RNSIVVGLAL FLSLSVPSYF QQYGLLPNTN SSVPTYFQPY NVASHGPVDT
GFGGVNYVLN TILSLNMVIA FLVAVILDNT VPGGCQERGL YVWSEAEEAT REPSFLKDYA
LPFKIGRVFR WVKCMGL
//
