ID A0A077RU01_WHEAT Unreviewed; 573 AA.
AC A0A077RU01;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=2-hydroxyacyl-CoA lyase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_043779 {ECO:0000313|EMBL:KAF7032625.1},
GN TRAES_3BF111600200CFD_c1 {ECO:0000313|EMBL:CDM81861.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EMBL:CDM81861.1};
RN [1] {ECO:0000313|EMBL:CDM81861.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25035497; DOI=10.1126/science.1249721;
RA Choulet F., Alberti A., Theil S., Glover N., Barbe V., Daron J.,
RA Pingault L., Sourdille P., Couloux A., Paux E., Leroy P., Mangenot S.,
RA Guilhot N., Le Gouis J., Balfourier F., Alaux M., Jamilloux V., Poulain J.,
RA Durand C., Bellec A., Gaspin C., Safar J., Dolezel J., Rogers J.,
RA Vandepoele K., Aury J.M., Mayer K., Berges H., Quesneville H., Wincker P.,
RA Feuillet C.;
RT "Structural and functional partitioning of bread wheat chromosome 3B.";
RL Science 345:1249721-1249721(2014).
RN [2] {ECO:0000313|EMBL:KAF7032625.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7032625.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3B02G486100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3B02G486100.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [4] {ECO:0000313|EnsemblPlants:TraesCS3B02G486100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [5] {ECO:0000313|EMBL:KAF7032625.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7032625.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; HG670306; CDM81861.1; -; Genomic_DNA.
DR EMBL; CM022218; KAF7032625.1; -; Genomic_DNA.
DR SMR; A0A077RU01; -.
DR STRING; 4565.A0A077RU01; -.
DR PaxDb; 4565-Traes_3B_0C313674A-1; -.
DR EnsemblPlants; TraesCS3B02G486100.1; TraesCS3B02G486100.1; TraesCS3B02G486100.
DR Gramene; TraesCAD_scaffold_003225_01G000600.1; TraesCAD_scaffold_003225_01G000600.1; TraesCAD_scaffold_003225_01G000600.
DR Gramene; TraesCLE_scaffold_021014_01G000400.1; TraesCLE_scaffold_021014_01G000400.1; TraesCLE_scaffold_021014_01G000400.
DR Gramene; TraesCS3B02G486100.1; TraesCS3B02G486100.1; TraesCS3B02G486100.
DR Gramene; TraesCS3B03G1203200.1; TraesCS3B03G1203200.1.CDS; TraesCS3B03G1203200.
DR Gramene; TraesPAR_scaffold_004113_01G000100.1; TraesPAR_scaffold_004113_01G000100.1; TraesPAR_scaffold_004113_01G000100.
DR Gramene; TraesROB_scaffold_045051_01G000400.1; TraesROB_scaffold_045051_01G000400.1; TraesROB_scaffold_045051_01G000400.
DR Gramene; TraesWEE_scaffold_002052_01G000400.1; TraesWEE_scaffold_002052_01G000400.1; TraesWEE_scaffold_002052_01G000400.
DR eggNOG; KOG1185; Eukaryota.
DR HOGENOM; CLU_013748_3_3_1; -.
DR OMA; MRVISFR; -.
DR OrthoDB; 1966690at2759; -.
DR Proteomes; UP000019116; Chromosome 3B.
DR Proteomes; UP000815260; Chromosome 3B.
DR ExpressionAtlas; A0A077RU01; baseline and differential.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IBA:GO_Central.
DR GO; GO:0001561; P:fatty acid alpha-oxidation; IBA:GO_Central.
DR CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR045025; HACL1-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR PANTHER; PTHR43710:SF2; 2-HYDROXYACYL-COA LYASE 1; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 14..124
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 209..333
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 405..556
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 573 AA; 60285 MW; 6BE678AC6571CF61 CRC64;
MASDSAARVD GSALAGRALA AAGARHMFGV VGIPVTSLAS RAAAAGCRFL AFRNEQSAGY
AAAAYGFLTG RPGLLLTVSG PGCVHGLAGL SHATANAWPL LMVSGSCDQR DAGRGDFQEL
DQIAATRPFA KLAVKAADIA DIPRLVFQAL AATVAGRPGG CYLDIPSDVL HQTLAESDAA
SLIAEAAAAA GSADPSPPKH KSLDQGIVEA AELLRRAERP LIVIGKGAAY ARAEVAIQKL
VDTTGIPFLP TPMGKGVVPD VHPLSSTAAR SLAIGQCDVA LVVGARLNWL LHFGEPPKWS
KDVKFILVDV SEDEIELRKP QVGLVGDAKK VVELLNREIK DQPFCLARSH PWVDAITKKS
KDNVLKMEAQ LVKDVVPFNF MTPMRIIRDA ILAEGSPAPV VVSEGANTMD VGRAVLVQNE
PRTRLDAGTW GTMGVGLGYC VAAAVAEPER LVVAVEGDSG FGFSAMEVET LVRYQLPVVV
IVFNNNGVYG GDRRGPDELT GPYKDDPAPT SFVPGAGYHK MMEAFGGKGY LVETPDELKS
ALSESFRARK PAVINVTIDP YAGAESGRMQ HKN
//
