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Database: UniProt
Entry: A0A077YYK0_TRITR
LinkDB: A0A077YYK0_TRITR
Original site: A0A077YYK0_TRITR 
ID   A0A077YYK0_TRITR        Unreviewed;      5172 AA.
AC   A0A077YYK0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   SubName: Full=Ryanodine receptor {ECO:0000313|EMBL:CDW52896.1};
GN   ORFNames=TTRE_0000115801 {ECO:0000313|EMBL:CDW52896.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW52896.1, ECO:0000313|Proteomes:UP000030665};
RN   [1] {ECO:0000313|EMBL:CDW52896.1, ECO:0000313|Proteomes:UP000030665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate
RT   host-pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HG805834; CDW52896.1; -; Genomic_DNA.
DR   Proteomes; UP000030665; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030665};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CDW52896.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030665};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4538   4558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4711   4730       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4769   4795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4960   4980       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5039   5058       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      367    425       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      623    847       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1082   1284       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4266   4301       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4302   4336       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4279   4290       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4314   4325       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     3949   3976       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5172 AA;  586363 MW;  8B7B9187DA5280D6 CRC64;
     MADNQENSAG EQDDISFLRT GDVVCLTCIA PSKETGTGSV ERVALAAEGF GNRLCYLENV
     SDRNVPPDHA TSMFYIHKAL SVRALREMMS CDTPGTAGSS SSHRTLLYGH AVQLRHVLST
     MYLTCLSTSS ATDKLAFDVG LCEADSSESC WWTIHPASKQ RSEGEKVRVG DDIILVSVAT
     ERYLHMSCSK GMTVIAAFHQ TLWSVTPNSS GSVRNRNLGY VFGNDVLRLY HGNDECLTIP
     ETWSDHSQQN IVIYEGGKSC SQARSLWRPE LLHGKWQGSL IGWEQVFRIR HVTSGRFLAV
     TADSQVSLVH KDKATFESTA FITVSSKNID SGKVFPALFN LAQDFLLAQF DVKRTSFEEK
     EEEGMGVPAL KYGETVTFLQ HLQTGLWLSC QTTAVTKKNV GKVEEKKAVA VEEARMDDCF
     VLFKAQGEEA QSARVIRKSS QILNRFLKGL EGLQFEGRDS QQWKRANLLE TVKLMEDLIE
     YFAQPKEEDF GLLTAVVDER EVPSLHSDFE TMQNRLRALR NRQDLFQEEG VLNMIIDTID
     QLSSVESTSE FSEVMKETGS REWEQISTYL YLLVAAMIKG NHSNCTQFAS AQRLDWLFNR
     LSNPQAAEGI LDVLYCILTE SPEALNLINE THVKSVISLL EKVGRDPKVL DVLSALCEGN
     GVAVRSSQNI ICNELVCNKN FLLQTRMVDQ VSSVMANIFI SVTEGCAIFK RWYFEAELEY
     MDSVGSSCLR PHLRVGWASS AGYVAYPGSG KKWGCNGVGD DMFSFGFDGK NMYAGGVKKT
     VGIRDLSRGD VIGCCIDLSI PEIRFSLNGN EVNTSFRGFS VADCLFYPVM SLSATVSCRL
     ILGDPHGKLR YGPPDGYLCV TEAAVTPIKI QPCIVYGDYR KGNFFGPSTV ISDFALFQPK
     PVDSREIILP KHLEDACDRL AENIHELWSM DKIEKGWKYG ERRSESQRIH PCLTNYERLP
     NAERAYNMNL ARETLKTVLA LSYRIDPGKL PNRVKTLRLP QNFLMSNGYK PSPLDTREIS
     LSESLNNLVE QLAKNLHNIW AQSKVQRGWT YSSVENSAFK TSPHLVSYEY LNPTIRAANR
     EKAGQIVKSL MVYGYTLEAP AMEIDEATTK QTEVLQMKLR TFRMERRYAV TSGKWYDFAI
     RMKSLAKCRS REQAANDLSF SQRYFEFEVR TPGFMSVGWM DVDSPPDTDL GTGKLSFGYD
     GYLGKKWHGE IEKFGKKWNV GDVVGCFLDL TDRIICFSLN GELLLDPSGA EMAFDNVNST
     GGLVPAFSLG PGQMCRVNFG QNVDSLKFYT TCGLQEGYEP FCIRMTRPAP LWINKFQPEF
     EEIGDDDRRF KVLRVVQSGD NPPCLKIQCK PTGLQERSSL TLFRLNLPVR CQHRSTKSTS
     ASGQASRSTL RESNRDDGAE TSSADTSRRG KPSVPERRRI EVSFVNGDCA TPSEKQQENA
     DPESTRRGSG FLTKTLSLDE DSSVVQRETL KPTVLRSSAS EVNLKDRDHN EVQNSKMSES
     MSSTSSKRSR KPFKVMQSFA QRMRDASIGR AKKHSAPKNE NTQKTRSRDV SSEGSNHFVS
     NREGVLAVDS SESLDMPKTG PGRRPTLIRM DSEKSKQRWN RYLSRGHEFL AEEMNLARQS
     IVQSLNSSLL PSSLAETYTE YYFGLRIYPG QDLANIWIGW LTPQFSYSVN NHLTSAFAQK
     VIFKEHDTNA TVNDQEFRSC YVVNALDLLA AVSGGSNVSK MSGLLVGCIV NTATGELTFH
     ANGRQTEMCF RVETGTLLYP TVFVIPTGKE VLQFELGRVE KTLPIASAQF NEMINGMQLQ
     CPPRLRIEIC KSRNWSLVPQ RCPRVTSLKL SDTRGWSILC DDVARLMMLY IPERDYSLDI
     LELIEYADLQ KFHQHTLQLY CSLCAHGNFK IAHILCRHVD EDQLTYAMKS KYLTGQLRQG
     FCDLLVAMHL SCHYNARMQS NKEYIIPLTE KLKSRNYFSV DCKGIYPHAV NSTVSMKPAM
     DVMSVKDNIS AKDEMFLRSP GFDFEALKSF VIDSLEEATV QALMHSRDLV GGTNTSHFAP
     LLKLFDTLLL VGLFTDEDVQ RLFRILNPSV FDDQQSSNVV YRNGLLSLEL DEEVQRHVCY
     VLSHLCDLLL QGRVETMISF AESFVGETQN DQLQRYMYIK QTDMPPAEAA RRTKEFRCPP
     KEQVGEGFTF GQRYSAKDLA KLLQFFKMMK LLNFKSNDCN MLDEEGEVEV SSMSEYLQNV
     LRSFHEGMIK CIGNKPVDDS APFSVDDIYA GDKPIDWVDK LALLVVPVPP DNGSGNTSLV
     PDGEEAFRKL IISTLIDWTS KKHIDDAILI REIFSLLLRQ YTRIDELMKA LKTTYCIHER
     SVDDVQRFIN HLSQIRRLLS VQFEAVDEEV LKDSLWQMMN NKVFFQHPDL MRLLKVHENV
     MTIMVNVLSR AQQGDAANRR TKDETNTNGN DFKNSISDLV VACCKFLCFI CRSSTANQAA
     MFEHLPFLLD NATMLLAKPS LRGSVPLDVA YYSFMDNSEL ALALKEDELE KVAFYLSRCG
     LQANAAMVAK GYPDIGWDPV EGERYVDFLR FCVWVNGECV EENANLVIRL LIRRPECLGP
     ALKGQGEGLL RAFKDAISLS TEIHNFNSGR NVRNRFMFDI TNYPNPADEN EDYIDMGAAI
     LGFYSSLVDL LGKCAPDPLT IKSGKSESLR LRSILRSLTS MDDLEGILAL RFLLPNVFAS
     NEESLKAPCY GLLPLHKSST LLFLERVYGL VDREMMFRLL EQSFIHDFRA ATILDHPSVA
     ESDLALALNR YLCGAVLPLL TNHAHFFAEA DHYSSLMDAT LHTTYRMSKI RSLTNNQRSA
     VTDFLLALTR EINPSMMSRL QQKVVKDISS LNEYAIVPLQ IMTQHYEHFS RHYGSSTIED
     VANEEQKRLS MLLFTTIFDS MGKRAFDQEL FARALPCLAA IASALSPDYA ASSPDRDEPH
     TPSADDADRE TVWKPVPVDV SHVQLSSGLQ NLVLLFAQHF HDSWASRKLE KGWKYGETYS
     RLNLTHPRLR PFGMLKEFEQ TFYKERCAEC MRAMLAMGYV IEEENPVPPT KPATQQITPR
     GSIIFSPQPV DLSNMSLSEE LSELAEKVAQ NSHLLWVAKA IDDLNVSNSG IIVQLVPWDI
     LTDTERRKHR FRAQEILKFL QYSGCRIKSP LPSGGSQGQQ SLMTQSGHRS AKTRFAYSLM
     EKMLLYIESA ALKMEVVKGS KRFSRGNTCT LASEDVKFFS KVLLPLLEAY FRSHRNYFIA
     TGSGVGIASM MEKEIVVNLF HRLMSSLRRR LAAFGCNIRT TVRCLQVLIS AIDFKSLVKA
     NSDSLRTCTQ VLFTYVVGDL TNIVKSIRKE GRYAEIRGKT LPCTSGLVYL NEVILPVLST
     LFNHLAQQGH GPDFLVNDIQ LSSYKIADSL YALSSLESPT RKSIKLELER HRSFIGQCLS
     AFACCFPVAF LEPEFNEVNK FSILTHLDQT SQSKELLSSI TADIPSLDKV LTDIEHLSQS
     GGNYQDAPAI FDVHVPTLCS YFSSWWQHGP NGTPADKPIT SVSSELVNRL FFACAKLICD
     HIGVQNANWV CHVAPFIQPM ISYVTAEPVK DCLLPMTEKI KEKANEAFRE EERQRTHPEL
     HSVLVRDIYA VFPLIIKFTD LHRARWLKNP SWETNSLYEN VAFIFKIWSV SQNMKREELN
     FITQLDADTF IGGSDLKTGK AAIAIRKKKR REGKKREKET NSIVVACLKR LLPVGLNVFG
     GRELELLQKI KEKHLKREPE ERIKEFIRSS LSVPDKEDMF DKSYWQRQLY HKIGKAQMLG
     ISSMNQEAVL EVITSMGLTL YNLHTVEHPQ TDLAGAWRKI LSSQRKRAVV ACFRMVALHS
     IPRHRCINIF LPAYAEKWME DENMDRDLLI CDLADFVEKG ASVKRTKDEA EEEDLQMPDS
     LSQLIQCFQR AATAERKQLV TIERDELYKE FVRVMAISIH IGEEEEDSNA DEAVNMEAQE
     LEKQELRHQQ ARLADRGAAV MVLMYLSACH GEPNEMVDGT LQLGIHILNG GNSMVQDMML
     AYLQDKKDVS FFSSIAGLMN RGSVLNLEIF ERQIKAEGLG MGAELSLGDH QNLNDAEFIC
     TLFRFIQLTC EGHNSEFQNY LRNQPGNTTS VNLIICTVDY LLRLQESIMD FYWHYFSKEL
     VDEAGKANFL RALSVCSQVF NTLTESVQGP CVGNQMALAN SRLWDAINGF FFLFANMMDK
     LSKNHTQLEL LREFLSLQKD MIVLMLSMLE GNVLNGSIGK QMVDTLAESQ QNVQLILKFF
     DMFLKLKDLT TSQAFQEFDL NKDGWISPKE FQRAMEGQKM YSIEEINYLM MCTDVNNDGK
     IDYMEFTERF HNPAKDIGFN LAVLLTNLKE HIVGDNRLDV ILQTASSMCD YFDPFLGRIE
     IMGSNKRVEK VYFEIKEEWL EQFNKPQIKQ SKKDFLFNVL QDDGGQQGKL EAFVNFCEDT
     IFEMSHAAEI SSEDKDSRVE RAKRQREIFT GQTERHDTIS PYDIVSLVFQ KLFFFIHLCY
     TSCRPSQLVK TKNQLRDSIA SMTYGQLFLS VCRISFKLVF MLAWLTYLIL STLLRFIYFM
     MGGSKEDDYV ALKSLPEPPA SRSLNRQRSF ISLLPDIEKS DVHKYEAFGL QLSQGTTEVE
     AANLATDHEA SKASFSFYIG GSFPAKSKLG SPTDDAQQAY SDAPFGSGSQ KSFEQDDKVR
     FQATAYEPKI ADVAPKSRGS IFNVLARNFY VLKYITLALA FLINAILLFY RVSVNTAEIS
     DSFAAQSESG NTTSSEVEVE EELSIHENYY YLTHVLKCLS VGHCLVSLAL LIAYYQLKVP
     LIIFKREKQV ARKLEFEGMW ITEMPSEDAV SGKWDSMVIS SATFPEKYWD KFVKRKVVEK
     YQDQFDIEEL HRLLGLDKQA LENAGNSGSR SVDWRYQMWK VGVIFADGSF QYLMMYLFFS
     AVGIWNPFFY AGHLIDVVFS FPMLQTILKS VTHNGKQLIL TVMMVVVVVY MYTVLAFNFF
     RKFYVQDEDG QETDSKCNNM ITCFVFNIYA GIRAGGGIGD ELQSPYGDEK EAWRILFDVT
     FYFFIIIILL AIMQGLIIDA FGDLRDQQES AQDKLEVRIM NCFELGDSSN CFICDIGKDF
     FERLPHGFEH HTAKEHNLAY YLFFLMHLIN KDETEYTGQE SYVWELYEKR CWDFFPVGEC
     FLKQYEDQLM MA
//
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