ID A0A077Z257_TRITR Unreviewed; 1781 AA.
AC A0A077Z257;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Neurogenic locus notch protein 2 {ECO:0000313|EMBL:CDW52690.1};
GN ORFNames=TTRE_0000095201 {ECO:0000313|EMBL:CDW52690.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW52690.1};
RN [1] {ECO:0000313|EMBL:CDW52690.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW52690.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; HG805829; CDW52690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077Z257; -.
DR STRING; 36087.A0A077Z257; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 13.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 23.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 11.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF02210; Laminin_G_2; 3.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 19.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 22.
DR PROSITE; PS01186; EGF_2; 20.
DR PROSITE; PS50026; EGF_3; 25.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1781
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001728320"
FT TRANSMEM 1720..1744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..62
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 64..106
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 140..178
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 182..218
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 220..256
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 258..295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 383..420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..467
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 469..509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..721
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 723..759
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 762..982
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 978..1014
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1042..1232
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1234..1270
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1272..1308
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1310..1346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1349..1390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1392..1430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1432..1468
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1470..1506
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1507..1543
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1545..1581
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1583..1620
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1622..1658
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1659..1705
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 30..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 52..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 96..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 149..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 168..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 208..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 246..255
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 285..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 372..381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 410..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 457..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 480..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 499..508
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 694..721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 749..758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1004..1013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1260..1269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1298..1307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1336..1345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1380..1389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1401..1418
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1420..1429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1458..1467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1496..1505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1511..1521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1533..1542
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1571..1580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1648..1657
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1695..1704
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1781 AA; 193350 MW; E2DB81B14EF91D6A CRC64;
MRWLCALLCY HTLVAVGRSS EAVLLESKDC VHYCLHQARC VAINGTIVKC VCQQGFGGSR
CEVLPSVCPP DVCSNGGSCF IKERDDFSDV IFECRCPDGF VGAHCESIDH CEQVCPPDSV
CKDGQCKCLS GTFGSPGGCI PKSCNPNPCL NGGSCVENGQ HGSAFCACKT GYDGTVCQQN
ITESRCSKES CPFGHICEET SQGISCRCPP GFAGPGCTIS VVDCVTVPCR NGGTCHPLNG
HFECRCPVGF SGALCNDDVD ECASNNSPCL HGMCNNIFGS YTCVCDEGWT GVNCSTRVKR
CSEELCLNGA TCVENGTTPY CKCATGFLGP KCEHELEERT TVNLQNAQCT VDADCYNGGV
CRDGSTGKMC VCSSGYSGGR CEVELSCSNA PCLNNGTCIG DSSSSLVCRC LPGYHGTFCE
YFAPNVSVRL RPSSSFCHYN PCQNGGTCDE ESKRCLCPFS FEGLLCELDV NECVSREVFC
PLEVSLGCEN HFGGYRCHCR PGYIGRDCLE PLVACHAHTC AERQQCRAEL NETTGRQYAE
CVCVPGTHNF PECDHSTVAS FNGQSMMVEI DVSTRTVYEV QLDFRTSLSN GFLIFGDDRF
GVNIYQVILV DGSLEIFSFS KTLIIGRRLN TDHWVHLSLV ANGSELTAKV QKEKDMFWQK
IPLDRPWTTT ISTRMGGTSA FHPYKPEVTN FVGCMRDVVV NGKTLVPSLI GASAVNVGFS
CNRSAQCYRS RCGARSRCVD LWDHSECECI PPFLPPNCST STPEATFGFE NNVSFALINI
SRLGVGGLDS VRYLDISMIV RTTALDGVLL YIGADAPRIT DCRNAYIGLQ LIEGRLDMAT
NLHNASKHFY QAGESSWSRI NDGQVHLVEL TYRPFLLKLS IDDQSVAVYR FVQSSVYDQT
ACASELLVLG GHPRSVKSVA HTVDNPFPLS TAKPFKGTVQ DIRVNDKPIQ LFGQDEPADK
SSSFGPVSMV NVLRGTHSDN ACQSNPCQNG GNCSVTFNDF SCQCAYGWLG KRCTIEHPCS
KHPCPSDTLC RLVAGTFDHA CHRPITFTNR SYSVVEMVPS EQFRAEHVAL KIRTRSVRGA
VLTLLQPTLS CALDISLKDG GLQLTLCNGT DVSFARGNVL LSDGQWHSLM IASSGGVLKV
SFDERIVAQL DTENCFANMF DRNVMTLWHF GNFQNRSIVL PVEDVSSFEG CLHDVSAGPE
TSLPITEPYD HRKGRHDHLF RIVSENNVKM NCVGEPVCAT ALCANDGSCQ DLWNAYECVC
PPGFAGKLCE VNIDDCDNAH CENGGTCVDE VADYHCNCLP GWAGKRCELN IDECLSQPCL
NGGVCVDKVD GFHCICPSNF TDPTCSTPVY VDCSSNPCAE GATCQNVPVG RDVVSFVCLC
APGFYGRHCE LVKNFCDGVT CLHNGTCRSL PAQLRFHCDC APGYEGHYCE EETDECLSEP
CHNGGTCVNE LNAFSCTCPH GWVGDTCDVD VDECLVNPCQ NNAQCINTEG GYYCQCQPYY
SGNACEIAGS CLQKPCLHGN CTQLSIEKHV CRCYNGYSGE SCSEMIDFCE SNPCKDGGEC
TAYPGGFNCT CFPGFTGNDC SENIDECHGE PCKNGGRCTD GNNGFSCDCS GTGYWGPTCD
VDVNECAIPG MCVHGKCHNM PGSYMCSCSS GYLGPKCDAV DPCALNESHR CKNDATCTGA
HWDSLREVVQ YKCLCQDSYE GEFCENRVQQ YKNPLISIEY VIGPIIGAIL IVVLFALAVL
VVFARKKNAT RGTYSPSVQE SNNARINLHH LVKAPPGERL I
//
