ID A0A077Z3K0_TRITR Unreviewed; 493 AA.
AC A0A077Z3K0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=TGF beta and TGFb propeptide domain containing pr otein {ECO:0000313|EMBL:CDW55077.1};
GN ORFNames=TTRE_0000334801 {ECO:0000313|EMBL:CDW55077.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW55077.1};
RN [1] {ECO:0000313|EMBL:CDW55077.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW55077.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; HG805934; CDW55077.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077Z3K0; -.
DR STRING; 36087.A0A077Z3K0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13763; TGF_beta_BMP3_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..493
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001728364"
FT DOMAIN 364..493
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 348..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55938 MW; 0538203201719EEB CRC64;
MAPESPKRLA VVFACWLLPL FVAWRHGDDG TVEQKPMPND LQKQVLHDTF KALLNYRRQA
ATASKNDTKR KSRSLMVASK YMKELFEQYK ANAGSSKVKG NIVRSISPTV GLMNGEAALI
FNLNAIRSRE AVIKAELHYH YGPRRRRSRR TPICLLLSPN GRKSEIKQVT WDRSGQWLAY
DVRNAVVSAV QSWSSQKAWR EGAGNVSAPV SIAVAFVGDA LLVPYAAKYF SPEKVLRHHA
PFLLVYSEEA QLIDRKQMLS AVLADRQRKK LNSPRPKRAI QNDNYFAYSM ANDYGIQSPT
EEARFAQQVR AFQERGPAVL QPMRSNRRRG SNRFELNSKF EQKRQPFGAK YVKHNRSRPP
LKTREREEKE DKQVDEQATV VLLKGSALQR CRKNNLLVDF RDIGWGEQII APKTFEAHYC
AGSCQFPLSS ISNPSNHAIL QSIIHTIGLQ PNVPQVCCSP DKMDSLTLLY FDEDQNVVLK
TYPKMVVTSC GCL
//
