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Database: UniProt
Entry: A0A077Z3K4_TRITR
LinkDB: A0A077Z3K4_TRITR
Original site: A0A077Z3K4_TRITR 
ID   A0A077Z3K4_TRITR        Unreviewed;      2203 AA.
AC   A0A077Z3K4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 18.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=TTRE_0000269901 {ECO:0000313|EMBL:CDW54429.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW54429.1, ECO:0000313|Proteomes:UP000030665};
RN   [1] {ECO:0000313|EMBL:CDW54429.1, ECO:0000313|Proteomes:UP000030665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate
RT   host-pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; HG805896; CDW54429.1; -; Genomic_DNA.
DR   Proteomes; UP000030665; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 6.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030665};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030665};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    308    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    443    464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    476    500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    949    969       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1008   1027       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1095   1119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1470   1488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1508   1529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1541   1559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1606   1628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1676   1693       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1723   1746       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1811   1832       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1844   1863       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2042   2062       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2131   2153       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      172    506       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      851    902       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1019   1129       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1469   1755       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1810   1872       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1972   2159       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1746   1783       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2203 AA;  247997 MW;  33F7021BCFAAC280 CRC64;
     MLEGPPPAEY RSFRSLSRAN RASICRKSRS SIVAPPSPTS KRRQSSGSPS VDGGKKSSPF
     VVPEVVNSQT QSTPPVGAET APARNNGSDS LARDLLSTNG EEENDSGLPY PSYSAKALLC
     LDQRTPPRSW CLRIVSNPYP FSSKRSRFFF EPFCHANRLQ GKCICFLNSL FTWFEKVSMM
     VILINCVTLG MYRPCDEDNV ATSCTTVRCK ILTTIDHMVF AFFAIEMVMK IIALGFYGGD
     QAYLSETWNR LDFFIVIAGC AEYIFKDQMG DINLTAIRTV RVLRPLRAIN RIPSMRILVN
     LLLDTLPMLG NVLLLCFFVF FIFGIVGVQL WAGLLRNRCL LNLPPTNDTN RELLGLMQYY
     MPDETSMEYI CSLEKDHGRH SCTNLQPSTY NGHICNLTID HWRSGSYSPQ NNSCINWNQY
     YTKCGPTSHN PFQGSVSFDN IGYAWVSIYL VISLEGWSDI MYYVQDAHSF WDWVYFVLLI
     VIGAFFMINL CLVVIATQFA ETKRRETERM MAERALYYSS STLATIDQPS ESDGVYRAIV
     KYIAHLGRRA KRKAMRYYRS YWQKSSDHSP ASLRELPIAY ASSAEPTTVA LPPKRSSIRR
     KRSMRQSAGR PSLANELALP SSRDSLSPSH CFSVPGAAAS SRDSSSLSFF SAIDDSIVGP
     SETGSCPPAF MHRKRCNSRR SNSRGKRLSD NSVMSTETMA SRLQTGDTLL AVRKPRKHYK
     LKHTESAPGG RTRADVQGRL LVNEPFLESG HSPGSEEDDD DRTIFSEDEA DGEQEDDEEE
     QDDNGGNDGA SAVAMKTFDT EKGRERVKFA DKRRSQFDGS ARSRKSRLCH FVQRLQNRVK
     RFVDGDHFTR GILVAILVNT LSMGIEYHNQ PEELTLVLEY SNILFTALFA VEMLLKLIAE
     GPIVELIQGG NGGLSVLRTF RLLRILKLVR FMPALRYQLI VMLRTMDNVT VFFGLLCLFI
     FIFSGRWHVY WFYSILGMNL FGCKFCRQEE APDGTQVRLC DRKNFDSLFW ATLTVFQVCI
     LITLLLLGME LFAGRFCHTV DGLPCPCKMK EVTCVCSRRN FDTFIQAAFT VFQILTQEDW
     NVVLFNGMAQ TSPWAALYFI ALMTFGNYVL FNLLVAILVE GFQESKEEEK RLLQEQQQDE
     ISGDICEPKK LPATETAVDR PLLTCTCAAA AAAAAAAAIL SGKHRERLLS LPALPMQFSC
     SDVGLAPPPI IQTLPTPADS PLLGRSVHTA DKSSESLSSN QENGHLKMDP NLSSYSSISI
     KSNSPRACTP QDGSSKRPCR NSMTYLGIPA YPSAHRKLQR HWSSVSSPTK PETIPEIGYS
     LSCEDNFKSL AASNPDERSS LAVPGALVAQ CNGGLSATAL PSLNGKRNSW LLKRDIPLSP
     MHSAKVGIPV PDSYSVEAIS RSGLLMSDQF GTVGYLSHRL KKSPKSLLRS WFHGWFEKSW
     FNTRMDYSLF LFSLKSSVRV KCIFLCEQKW FDFFILTFIG INCVTLAMER PDIPPMSVER
     MFLDVSNYVF TAVFAVEMLI KVIAKGLVLG DKAYFKNGWD FMDGTLVIIS FCNLLFDLLH
     RTDAPRIFSV VRVLRLLRAL RPLRVINRAP GVKLVVQTLI SSLKPIGNIV LICCTFFIIF
     GILGVQLFKG KMWHCVGPSV AHVVNKTDCL ADPHNRWVNH RNCSSWLQQS MMRCKIFNLF
     SFKALMSLFV VASKDGWVSI MYQGIDAVAV DMQPVVNYFE WRMLYFISFL LLVGFFVLNM
     FVGVVVENFH RCKEALEKEM KEKEREKKMR KRLQKQMSRQ QLLMKKAHKL PYWYHYGATR
     LYIHSIVTSK YFDLAISAVI GVNVITMAME FHMMPAELSY TLKVFNYFFT VIFTLEAMVK
     IYALGIRHYL IDSSGSNKGL KPMFQNFGKH RHSLVMNTMS SRNAGAKGYT VFVKAIILNV
     CQPDVNASKM TISLWQHLYV QLNEISHYCT TGFNCSPCAV ELFCSTQSGF RWNQLDVLIV
     ILSISGIILE EMESKVLPIN PTIMRVMRML RIARILKLLK MAKGIRSLLD TVMQALPQVG
     NLGLLFFLLF FIFAALGVEL FGRLECSDEH PCDGLGEHAH FKNFGIAFLT LFRIATGDNW
     NGIMKDTLRD DCDNSDHCAT NCCVSAIIAP IYFVVFVLMA QFVLVNVVVA VLMKHLEESS
     KKMADGSSET GGSAATDSDA FMRSDTDDEK GPKFGIDLLE EFS
//
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