ID A0A077ZBC3_TRITR Unreviewed; 936 AA.
AC A0A077ZBC3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 22-FEB-2023, entry version 39.
DE SubName: Full=SH2B adapter protein 2 {ECO:0000313|EMBL:CDW57652.1};
GN ORFNames=TTRE_0000594501 {ECO:0000313|EMBL:CDW57652.1};
OS Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW57652.1};
RN [1] {ECO:0000313|EMBL:CDW57652.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDW57652.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT "The whipworm genome and dual-species transcriptomics of an intimate host-
RT pathogen interaction.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the IWR1/SLC7A6OS family.
CC {ECO:0000256|ARBA:ARBA00010218}.
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; HG806195; CDW57652.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077ZBC3; -.
DR STRING; 36087.A0A077ZBC3; -.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10346; SH2_SH2B_family; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035057; SH2B1_SH2.
DR InterPro; IPR013883; TF_Iwr1_dom.
DR PANTHER; PTHR10872:SF2; LNK, ISOFORM D; 1.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR Pfam; PF08574; Iwr1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 487..599
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 770..863
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 235..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 103742 MW; E32F28015A0ACC7B CRC64;
MDPELTTEHQ FDAVSAMNSQ TPPVVLRVKR KAGIGANSSL VMVPKKCRRS GEGDGPTSFV
ADLVHSGSRS SPAELVTSLK RALPSQVLDD LATSSKRLRV IDLEMSDNFP SSLKVTGNEY
LLLDKAVLTS PLAVDTPDGE NSVHELISQF GAMEAFNELE SFVSEDTSGA SANARSPITM
NGVPLLRSSC VDNYDYYVAD ACDESFLNWD MMTDDINEMF AFEMVGKPGS FVDDWSSCGD
EDDSEDSNAE NYFRNDYPDE ESEDDADVSG SSSDASLQRP KESNFRLRTS VMLSVNVGSL
RRGKDSAKSS SVAWEEFCDS CAKFAAYDFA QSWHNYLAEN PTAIDKVSEQ EVASKFVDAF
VRYFENEARR ICRTSRLLND SVVSNGSHSL FTSESALCRN GGARAQYVNS LCSSETDSDC
SNSNLSHEFS LKKKRGLFSR LSYKSVKRSL FKKPSLEESV FPDSCKSERP LSKQRNRSKT
CAKTVVEIIH EGSVNFICGR ELDREKWEKG RMVLVKTVGG YLLEFYAPPK ASKPKNGIFC
FLITEVRETT ALETPDCDNT FVLKAMSAFL AENLKEYIVQ AKSRREMREW LSAISSCTDD
SLGASTGADS SERLNMIGSA SAKSEGAFRC GDFHSLPLRG GLFTSRRSYL FSQYSSVCAG
SSATRKAHMR LSSIFAAREF PVRSSGNHLF SSSQLRRSYS SSQASNPTTS VRHHLRSSGS
ALLNGLRGLQ MSAGALHDTS TCPFGNLFGT YAGRWLVISG IRRMLEKYPW FHGNLSRNDA
TTLVIQSGVE GHGLFLVRQS ETRSGEYVLT FSCFGRAKHL RMTVLGRGQC RVQHLWFDSV
FDMLEHFRTH HIPLQTNARE GPSSNGGVLL TDYVIAWPPN QPHQRTTPAD PRNYMTHGGS
VRMTAHSLEQ LAIEQGQPQQ QQTIWQGRAE NTYQFT
//
