ID   A0A077ZK08_TRITR        Unreviewed;       565 AA.
AC   A0A077ZK08;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE            EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE   AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN   ORFNames=TTRE_0000728901 {ECO:0000313|EMBL:CDW58960.1};
OS   Trichuris trichiura (Whipworm) (Trichocephalus trichiurus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=36087 {ECO:0000313|EMBL:CDW58960.1};
RN   [1] {ECO:0000313|EMBL:CDW58960.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Aslett M.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDW58960.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate host-
RT   pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC         glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC         Evidence={ECO:0000256|RuleBase:RU361180};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC       {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
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DR   EMBL; HG806465; CDW58960.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A077ZK08; -.
DR   STRING; 36087.A0A077ZK08; -.
DR   GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR001661; Glyco_hydro_37.
DR   PANTHER; PTHR23403; TREHALASE; 1.
DR   PANTHER; PTHR23403:SF12; TREHALASE; 1.
DR   Pfam; PF01204; Trehalase; 1.
DR   PRINTS; PR00744; GLHYDRLASE37.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|RuleBase:RU361180};
KW   Hydrolase {ECO:0000256|RuleBase:RU361180}.
SQ   SEQUENCE   565 AA;  65575 MW;  C71820D2F6583151 CRC64;
     MMYYVVSLLS QIYCHGPILD AVQKSHLYPD SKHFVDMALK QDPVITLQDF LALGDTVNDK
     EVLHKFVESH FDPPGTELEV CFPEDWRPAP RSFNAIKDYE LRRWAQTLNR MWKELCRKVR
     KEVRDHQELF SLLYVPNAFI IPGGRFREFY YWDTFWIVKG LLASDMFSTV RGMIRNLGYM
     VENHGFVPNG GRIYYLYRSQ PPLLIPMVYD YYLATGDIDF LDEMLPLLEK EYRFWLRKRG
     STYSVSNKTF DVFQYKAEMK IPRPESYRED LELVENLTSL SEREKVWAQI VSGAETGWDF
     SSRWFSHSGP EAYSLRSIRT WSIIPVDLNA FMCLNTKLLA NMYEMVGNLT KVLQYQARFH
     EAKLAMKKIH WNEEDGIWYD YDLENQRHVD VYYISNVLPL YANCYDDENA PSRVFQYLKA
     VGAFNSSRGI PTSFIQTDQQ WDSANAWPPM VHMLIEGFRT SGDPDLTASA QHLATQWLHS
     TYRAYMHTNA MFEKYNVSDV NELPSGGGGG EYEVQTGFGW TNGVILDLLA KYGDCVTAAG
     SSSFSSLRLL VISTVLLFCK FQIIP
//