ID A0A077ZP28_STYLE Unreviewed; 657 AA.
AC A0A077ZP28;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 28-JUN-2023, entry version 29.
DE SubName: Full=Medea {ECO:0000313|EMBL:CDW71140.1};
GN Name=Contig403.g443 {ECO:0000313|EMBL:CDW71140.1};
GN ORFNames=STYLEM_79 {ECO:0000313|EMBL:CDW71140.1};
OS Stylonychia lemnae (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW71140.1, ECO:0000313|Proteomes:UP000039865};
RN [1] {ECO:0000313|EMBL:CDW71140.1, ECO:0000313|Proteomes:UP000039865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=130c {ECO:0000313|EMBL:CDW71140.1,
RC ECO:0000313|Proteomes:UP000039865};
RA Swart Estienne;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; CCKQ01000078; CDW71140.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A077ZP28; -.
DR EnsemblProtists; CDW71140; CDW71140; STYLEM_79.
DR InParanoid; A0A077ZP28; -.
DR OMA; VEMPINI; -.
DR OrthoDB; 181144at2759; -.
DR Proteomes; UP000039865; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000039865};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 393..498
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 512..638
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 657 AA; 77520 MW; 950190DFD0527ED0 CRC64;
MSNLQTNKNS VLESAINQIG QEQSEIFVEN LKFHLCAEEQ YEKVEQSLNV KEQKIIQIPI
NKNSILYSGL HSHCYVKLDS NYTPISYNER QKYKSIMTFQ DVDQVKKFYK SVQHFESELF
EEPYLLFNEI SIQLCYQNIK RCKPKNPKER KKYCSLYLQK FQIDEKIDPK IMNDCFEQFR
PIEFNEEVYA RQNQIDKMTI LEYFNVYLHQ SFCPVCLIFM CPRHLDGSNE RNPWIFQRIR
QLPQVQGFDL ENLKQEKNNY YLNDWIFKME GNCDQMVKVN NLRCDSFDSA QCHYQQNHVK
IEKKEQIRNI PIILKNNITL IIKQFQTVNP CFIVKLFNSY GQRNLKCLQI CLIVEFIVQE
KLKEGETLIM PPIVISHHDL TKFHETSYFE NYLKKNQHAY FDSEGIPFHY VPCDHEGPCN
QNCQCVQKNL LCDSYCSCKY FCLNAFPGCN CKSENDCQNK AKCLCLKNNR ECDPNKCRSC
KSYINQNIPK KADGSNVSSS DKVLCKNVHL GQKLPLKKVF TAKSTLCDEI VGLFAGEKIK
KEKIIMEYTG KALIQDGPKE QMDQLINDFR GRSYGFTLDK SITLDAVYIG NLMRFVNHSH
DKLANCYVKM VFSQGQQRVC LISRRQIETG EELFFDYQFK QDFDWLSDYR QRYTDCL
//
