ID A0A078ASJ2_STYLE Unreviewed; 420 AA.
AC A0A078ASJ2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=acetyl-CoA C-acyltransferase {ECO:0000256|ARBA:ARBA00024073};
DE EC=2.3.1.16 {ECO:0000256|ARBA:ARBA00024073};
GN Name=Contig11882.g12714 {ECO:0000313|EMBL:CDW85139.1};
GN ORFNames=STYLEM_14209 {ECO:0000313|EMBL:CDW85139.1};
OS Stylonychia lemnae (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX NCBI_TaxID=5949 {ECO:0000313|EMBL:CDW85139.1, ECO:0000313|Proteomes:UP000039865};
RN [1] {ECO:0000313|EMBL:CDW85139.1, ECO:0000313|Proteomes:UP000039865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=130c {ECO:0000313|EMBL:CDW85139.1,
RC ECO:0000313|Proteomes:UP000039865};
RA Swart Estienne;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CCKQ01013474; CDW85139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A078ASJ2; -.
DR EnsemblProtists; CDW85139; CDW85139; STYLEM_14209.
DR InParanoid; A0A078ASJ2; -.
DR OMA; MDHLPGC; -.
DR OrthoDB; 5481312at2759; -.
DR Proteomes; UP000039865; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:CDW85139.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000039865};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:CDW85139.1}.
FT DOMAIN 34..289
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 298..419
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 119
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 376
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 406
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 420 AA; 44597 MW; 11521CBD17FBBA50 CRC64;
MESAQRSLSI INNQFASNQT MNAGKVLDKS DDDVVIVGMA RTAITKGKRG AQKDTAPELM
LTPVLQAVIK QANIDPKLVE DVAIGNVLQP GAGATTSRIA MFLAGLPASS SLQAINRQCS
SGLQAVMSIA NAIRARQIDF GIGGGVESMS LYSMEAGVDP NTLSSKAFEH PVAQNCLMPM
GITSENVAEQ YKISREKQDQ MAFESHQKAA RANKEGWAQK EITSYKTMVK DKDGNEKEVL
VDRDDGVRAE TTLEGLKKLK PAFKKDGTTT AGNSSQVSDG ASAVLLTRRD VAKKLGLKVY
GRIVSYAVAG VPPEIMGVGP AYAIPAALKK AGLEVKDIDV FEINEAFASQ ATMSIEALGV
PKEKLNPRGG AIAIGHPLGN TGSRQVVTLF HELERTAKRF GVISMCIGTG MGAAGVFERE
//
