ID A0A078GDN3_BRANA Unreviewed; 1189 AA.
AC A0A078GDN3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=BnaC09g19010D {ECO:0000313|EMBL:CDY23147.1};
GN ORFNames=GSBRNA2T00021668001 {ECO:0000313|EMBL:CDY23147.1};
OS Brassica napus (Rape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY23147.1, ECO:0000313|Proteomes:UP000028999};
RN [1] {ECO:0000313|EMBL:CDY23147.1, ECO:0000313|Proteomes:UP000028999}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999};
RX PubMed=25146293; DOI=10.1126/science.1253435;
RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., Chiquet J.,
RA Belcram H., Tong C., Samans B., Correa M., Da Silva C., Just J.,
RA Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., Noel B.,
RA Labadie K., Alberti A., Charles M., Arnaud D., Guo H., Daviaud C.,
RA Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., Tack D.,
RA Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., Renault V.,
RA Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., Chalabi S., Hu Q.,
RA Fan C., Tollenaere R., Lu Y., Battail C., Shen J., Sidebottom C.H.,
RA Wang X., Canaguier A., Chauveau A., Berard A., Deniot G., Guan M., Liu Z.,
RA Sun F., Lim Y.P., Lyons E., Town C.D., Bancroft I., Wang X., Meng J.,
RA Ma J., Pires J.C., King G.J., Brunel D., Delourme R., Renard M., Aury J.M.,
RA Adams K.L., Batley J., Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W.,
RA Sharpe A.G., Paterson A.H., Guan C., Wincker P.;
RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic
RT Brassica napus oilseed genome.";
RL Science 345:950-953(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; LK032140; CDY23147.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A078GDN3; -.
DR PaxDb; 3708-A0A078GDN3; -.
DR EnsemblPlants; CDY23147; CDY23147; GSBRNA2T00021668001.
DR Gramene; CDY23147; CDY23147; GSBRNA2T00021668001.
DR OMA; RRTQHEG; -.
DR Proteomes; UP000028999; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF344; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028999}.
FT DOMAIN 14..178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1142..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 134027 MW; 5C80F034106C8A8D CRC64;
MATSTSSNPV HQPPQHKVFL NFRGADLRLN FISHLVGALQ MEGINYFIDE DEMRGEKLEK
LFKTIEESSI AIVVISSKYT ESEWCLNELA KIKESTQIKC VEEERMRVFP VFYKVTVASV
KDKKGNFRDY LTKLSSDRKE TWENALDFVT SRLGQTVDEK SCEGTAIKAI VKAVMRLLDD
ISTKRADGRG GTQKKLLTEK GAEDRTCSDT SSLYGMETRT KQLEDKLELQ PKVTRIVGVV
GMPGIGKTTL AKKVLEKQRQ RCKFMYTVYL GEICKKSKLL PLNRLHEDLL LELYNWKNNG
NEKQQMNSNF SLDKFKAGLS KKKIFVVLDD VSDKKQLDAI LENREWICEG SKIVIITRSE
SAVKGIVNDT FFVPGLSHID ALKLFNYHAF SSADYCGDPG LRKLAEEFVD YTRGHPLALK
VLGGELHLKD KAYWESKRAM LTQGLSNIIQ DGLRVPYDDL SEHHKNVFLD IACFFRFGDE
NHVKSLLDSS LHDDDIKVLA DKFLINICAG RLEMNDMFYT LAMGLLSQAS AENTKSGCRL
FNHGDIVGVL NTKAQATKVR GIFFDVSQVT KNVMLDSDTF ASMGDLRYLK FYNSRCPKVC
ESECTVNFPD GVEFTLQEIR YLHWLKFPSE KFPQEFDPRN LIDLKLPYSK MEQIWDGDKD
ASKLKWLDMN NSCKLRTLTG LSQARNLQTL NLEGCTELKA VHEEVQNMDS LVFLNLRGCT
SLESLPEMNL IALKTLILSG CSRFEEFHIV GKNLEELYLD GTVIKGLPST IGDLQSLVLL
KLNDCVHLSS LPDTVGNLKA LEKLILSGCS KLETLPKFQT ALKTLLFDRT GIYFPQQLPC
GSFLLSSVRH LCLSRNIFKS LPSEISLLYH LKWLNLKYCK ELSSVPVLPP NLELLDAHGC
ISLEKVADPS PLWLGETKHV HSTFNFSNCN KLDQVAENSI ETYVRRKIQL MSNAVALYDE
GFFLDVSIRI CYPGWQLPVW FSHRMVGSVL KAELPRHWSD GGITGIALCA VVSFANSQTQ
NSRLSVRCTG EFTEKNRSRI RFNCILGGCN EHDSDKPMEI VSSHVFIGYM SWSHINKCNG
ETDNRNDCVA TEASVKVQVI DGTRQVTNCE VLKCGFSLIY ASTEADHGLS PKKSSGVISA
TNDVIHGDTG SNTQSEESYD AASSRKDSEI SEERGSETDY DAVKWLYLQ
//
