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Database: UniProt
Entry: A0A078IHK3_BRANA
LinkDB: A0A078IHK3_BRANA
Original site: A0A078IHK3_BRANA 
ID   A0A078IHK3_BRANA        Unreviewed;      1431 AA.
AC   A0A078IHK3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=DNA (cytosine-5)-methyltransferase {ECO:0000256|PIRNR:PIRNR037404};
DE            EC=2.1.1.37 {ECO:0000256|PIRNR:PIRNR037404};
GN   Name=BnaA09g42250D {ECO:0000313|EMBL:CDY49442.1};
GN   ORFNames=GSBRNA2T00093026001 {ECO:0000313|EMBL:CDY49442.1};
OS   Brassica napus (Rape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY49442.1, ECO:0000313|Proteomes:UP000028999};
RN   [1] {ECO:0000313|EMBL:CDY49442.1, ECO:0000313|Proteomes:UP000028999}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999};
RX   PubMed=25146293; DOI=10.1126/science.1253435;
RA   Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., Chiquet J.,
RA   Belcram H., Tong C., Samans B., Correa M., Da Silva C., Just J.,
RA   Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., Noel B.,
RA   Labadie K., Alberti A., Charles M., Arnaud D., Guo H., Daviaud C.,
RA   Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., Tack D.,
RA   Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., Renault V.,
RA   Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., Chalabi S., Hu Q.,
RA   Fan C., Tollenaere R., Lu Y., Battail C., Shen J., Sidebottom C.H.,
RA   Wang X., Canaguier A., Chauveau A., Berard A., Deniot G., Guan M., Liu Z.,
RA   Sun F., Lim Y.P., Lyons E., Town C.D., Bancroft I., Wang X., Meng J.,
RA   Ma J., Pires J.C., King G.J., Brunel D., Delourme R., Renard M., Aury J.M.,
RA   Adams K.L., Batley J., Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W.,
RA   Sharpe A.G., Paterson A.H., Guan C., Wincker P.;
RT   "Plant genetics. Early allopolyploid evolution in the post-Neolithic
RT   Brassica napus oilseed genome.";
RL   Science 345:950-953(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037404,
CC         ECO:0000256|RuleBase:RU000417};
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC         Evidence={ECO:0000256|ARBA:ARBA00034078};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR037404}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family.
CC       {ECO:0000256|PIRNR:PIRNR037404, ECO:0000256|PROSITE-ProRule:PRU01016,
CC       ECO:0000256|RuleBase:RU000416}.
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DR   EMBL; LK032833; CDY49442.1; -; Genomic_DNA.
DR   STRING; 3708.A0A078IHK3; -.
DR   PaxDb; 3708-A0A078IHK3; -.
DR   EnsemblPlants; CDY49442; CDY49442; GSBRNA2T00093026001.
DR   Gramene; CDY49442; CDY49442; GSBRNA2T00093026001.
DR   OMA; GAVIQME; -.
DR   Proteomes; UP000028999; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; IBA:GO_Central.
DR   CDD; cd04712; BAH_DCM_I; 1.
DR   CDD; cd04708; BAH_plantDCM_II; 1.
DR   Gene3D; 2.30.30.490; -; 2.
DR   Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR006058; 2Fe2S_fd_BS.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR031303; C5_meth_CS.
DR   InterPro; IPR022702; Cytosine_MeTrfase1_RFD.
DR   InterPro; IPR017198; DNMT1-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR00675; dcm; 1.
DR   PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR   Pfam; PF01426; BAH; 2.
DR   Pfam; PF00145; DNA_methylase; 2.
DR   Pfam; PF12047; DNMT1-RFD; 3.
DR   PIRSF; PIRSF037404; DNMT1; 5.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SMART; SM00439; BAH; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00197; 2FE2S_FER_1; 1.
DR   PROSITE; PS51038; BAH; 2.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS00095; C5_MTASE_2; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037404};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|PIRNR:PIRNR037404};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037404};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028999};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRNR:PIRNR037404};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037404}.
FT   DOMAIN          632..770
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   DOMAIN          810..947
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..590
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1096
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037404-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   1431 AA;  162099 MW;  CD06A3AB6C03D149 CRC64;
     MVRNGTKAGE QKKRPLPEIK ADSDGEDLST RHTRPKRAAA CTNFKEKSVR ISEKSATVET
     KQHQTVEDEV EKGRGVKCDG FGRVENWSIS GYDDGYPVVW FSTELADYDC GKPATSYKKM
     YDYFYQKAFA SVEVYKRVAK SAGGDSGVSL DELLVAVSRS MSLESKCFST DFLVIRNFLI
     RQGEFIYNQL AGLDETAKKD EASFAEIPVL VALRDENSRL DNGAVIQMEG RPSNGVLRID
     GVSEAAKCEA LISDQEMVDE DQRYARIMQD EEDRKTMQRP KRNNGAALAS NKGYVKTTED
     EIAGDYPLPA YYKNFKDEAD ELIVADDYEV NYEDLPRRML HNWALYNSDS RFISLELLPM
     KPCADIDVTI FGQIKEWMIE WGCSTISISI RTDVAWYRLG KPSKQYAPWF EPVLKTARVT
     IGIFGLLEEQ TRMSKLSFED VTKRVSEFQK NDKAFISSDR LAVNRFLVGH GQIILQMFSE
     FPKKDIQRCS FVSDLARKRA ERHNTRWTIK KKKILFKVNC NPRAGMAPVV SKRKAMQATT
     TRLINRIWGE FYSNYSPEEP VQAVGVENEE EEVEEEGEIE EDDAEETVPE PVEEVEKFHT
     PLKKIRGVSG KTESSWSGES LGKTSAGEPL YRQALVGEEI VAVGGAVVLE DEGNEVIYFV
     EYMFEKSNNC KMLHGRLLQR GCDTVLGNAA NERELFLTNE CKTVSLKEIK GTVSFEIRSR
     PWGHQFRKEN TTADKLDRAR AEERKTKDLP TEYFCKSLYS PERGGFFSLP LNDMGCASGT
     CSSCRIREDE EKKTEIKLNS SKTGFSCNGV DYSDDDYVYV KPEDIDGSKE ANGRFKSGRN
     IGLRPFVVCQ ILEIIVLKES RKASFEVKVR RLYRPEDVSD EKAYASDIQE LYYSEDTDVL
     QPEALEGKCE VRKKIDMPSR REYPISDNIF FCEQIYDPSK GSLKQLPVNI KPKYTTVKDE
     ALLRKRKGKG LVTETDSVTD KPEEVSKETR LATLDIFAGC GGLSQGLEQA GVSATKWAIE
     YEEPAGKAFR KNHPETTVFV DNCNVILRAI MEKCGDQDEC ISTKEANELA EKLDEDQKRT
     LPLPGQVDFI NGGPPCQGFS GMNRFNQSSW SKVQCEMILA FLSFADYFRP RYFLLENVRT
     FVSFNKGQTF QLTLASLLEM GYQVRFGILE AGAYGVSQSR KRAFIWAAAP DEVLPEWPEP
     MHVFGVPELK ISLSKGVHYA AVRSTQYGAP FRPITVRDTI GDLPSVVNGE SNTKREYKSQ
     PISWFQKEIR GDNIALTDHI CKEMNELNLI RCKKIPKRPG ADWRDLPEEK VTLSKGQVVD
     LIPWCLPNTA KRHNQWKGLF GRLDWEGNFP TSITDPQPMG KVGMCFHPDQ DRIITVRECA
     RSQGFPDSYV FQGNIIHKHR QIGNAVPPPL AFALGRKLKE AVQLKSVTKT N
//
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