ID A0A078J1D1_BRANA Unreviewed; 1284 AA.
AC A0A078J1D1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=BnaAnng15960D {ECO:0000313|EMBL:CDY59311.1};
GN ORFNames=GSBRNA2T00025870001 {ECO:0000313|EMBL:CDY59311.1};
OS Brassica napus (Rape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY59311.1, ECO:0000313|Proteomes:UP000028999};
RN [1] {ECO:0000313|EMBL:CDY59311.1, ECO:0000313|Proteomes:UP000028999}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999};
RX PubMed=25146293; DOI=10.1126/science.1253435;
RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., Chiquet J.,
RA Belcram H., Tong C., Samans B., Correa M., Da Silva C., Just J.,
RA Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., Noel B.,
RA Labadie K., Alberti A., Charles M., Arnaud D., Guo H., Daviaud C.,
RA Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., Tack D.,
RA Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., Renault V.,
RA Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., Chalabi S., Hu Q.,
RA Fan C., Tollenaere R., Lu Y., Battail C., Shen J., Sidebottom C.H.,
RA Wang X., Canaguier A., Chauveau A., Berard A., Deniot G., Guan M., Liu Z.,
RA Sun F., Lim Y.P., Lyons E., Town C.D., Bancroft I., Wang X., Meng J.,
RA Ma J., Pires J.C., King G.J., Brunel D., Delourme R., Renard M., Aury J.M.,
RA Adams K.L., Batley J., Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W.,
RA Sharpe A.G., Paterson A.H., Guan C., Wincker P.;
RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic
RT Brassica napus oilseed genome.";
RL Science 345:950-953(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; LK033749; CDY59311.1; -; Genomic_DNA.
DR PaxDb; 3708-A0A078J1D1; -.
DR EnsemblPlants; CDY59311; CDY59311; GSBRNA2T00025870001.
DR Gramene; CDY59311; CDY59311; GSBRNA2T00025870001.
DR OMA; EREWEST; -.
DR Proteomes; UP000028999; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF524; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000028999};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 15..178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1219..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 145923 MW; D3B451D926E6C97D CRC64;
MASLPCHSPS ASAIWKTDVF VSFRGEDVRK TFVSHLFCEL DRMGINAFRD DLDLERGKHI
SSELVDTIRG SRFAVVVVSR NYASSSWCLD ELLEIMERKN TVDQKTIIPV FYEVDPSDVR
RQTGSFGEGV ESHSDKKKVM KWREALTQLA AISGEDSRNW RDESKLIKKI VKDISDRLVS
TSLDDTDELI GMSSHMDFLQ SMMSIEEEDV RTVGIWGMGG VGKTTIAKYL YNKLSSRFQA
HCFMENVKEV CNRYGVERLQ GEFLCRMFRE RDSVSCSSMI KERFRRKRVL IVLDDVDRSE
QVDGLFKETG WFGPGSRIIV TTRDRHLLVS HGIELIYKVK CLPEKEALHL FCNYAFRNET
IAPEFRVLAV QAVNYASGLP LALRVLGSFL YRRGEREWES TLARLETSPH SDIMEVLRVS
YDGLDEQEKA IFLYISCFYN MKHVDYATRL LDICGYAAEI GITVLTEKSL IVISNGCIKM
HDLVEQMGRE LVRRQAERFL LWRPEDICDL LSETTGTSVV EGMSLNMSEV SEVLASDQGF
EGLSNLKLLN FYDLSYDGET RVHLPNGLTY LPRKLRYLRW DGYPLNSLPS RFHPEFLVEL
CMSNSHLHYL WNGIQPLRKL KKMDLSRCKY LIEIPDLSKA TNLEELNLSY CQSLTEVTPS
IKNLQKLYCF YLTNCTKLKK IPSGIALKSL ETVGMNGCSS LMHFPEFSWN ARRLYLSSTK
IEELPSSMIS RLSCLVELDM SDCQSIRTLP SSVKHLVSLK SLSLNGCKHL ENLPDSLLSL
TCLETLEVSG CLNINEFPRL AKNIEVLRIS ETSINEVPAR ICDLSQLRSL DISGNEKLKS
LPVSISELRS LEKLKLSGCC VLESLPPEIC QTMSCLRWLD LERTSIKELP ENIGNLIALE
VLQAGRTAIR RAPLSIARLE RLQVLAIGNS FYTSQGLHSL CPHLSIFNDL RALCLSNMNM
IEIPNSIGNL WSLSELDLSG NNFEHIPASI RRLTRLSRLD VNNCQRLQAL PDDLPRRLLY
IYAHGCTSLV SISGCFKPCC LRKLVASNCY KLDQEAQILI HRNMKLDAAK PEHSYFPGRD
VPSCFNHQAM GSSLRIRQPS SDILGFSACI MIGVDGEYSM NDLKIRCSCI LKRVDDAQEL
VVMDELWYPD PKAFANMSFG SDHLLLFSRS CMSMGAYNEV FFEFSIENTN GDSSTNLLVE
VKKCAVHLIT FKDMLQEEHE SSSSSQQFSN DDNENIHDPD LEELDEAGVP KRRPDDLHKE
QPNPKKIKFL PVPSKLHQLI DTPQ
//
