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Database: UniProt
Entry: A0A078KKV3_9FIRM
LinkDB: A0A078KKV3_9FIRM
Original site: A0A078KKV3_9FIRM 
ID   A0A078KKV3_9FIRM        Unreviewed;       443 AA.
AC   A0A078KKV3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CDZ23152.1};
GN   ORFNames=CCDG5_0001 {ECO:0000313|EMBL:CDZ23152.1};
OS   [Clostridium] cellulosi.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminiclostridium.
OX   NCBI_TaxID=29343 {ECO:0000313|EMBL:CDZ23152.1, ECO:0000313|Proteomes:UP000032431};
RN   [1] {ECO:0000313|EMBL:CDZ23152.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wibberg Daniel;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; LM995447; CDZ23152.1; -; Genomic_DNA.
DR   RefSeq; WP_045085053.1; NZ_LM995447.1.
DR   EnsemblBacteria; CDZ23152; CDZ23152; CCDG5_0001.
DR   KEGG; ccel:CCDG5_0001; -.
DR   PATRIC; fig|29343.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000032431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032431};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032431}.
FT   DOMAIN      138    266       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      350    419       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     146    153       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   443 AA;  50220 MW;  89D74AEDF541199F CRC64;
     MQSFSEVWSG VCSYCSKLIS NTAMNTWINS IEPMELKNDE AILFVRSDFQ RQIIMSRYLD
     YLKDGFKETL GFPVKITILT EEDKPDAVSK PGQPSSKDIE QTYADAEYEY TFDTFIVGSS
     NKFAHAASLA VASNPAKAYN PLFIYGGSGL GKTHLLHAIQ HEIKKNHPEM NIVYINGEDF
     TNELVESIRQ NNQMQFRNKY RQSSVLLVDD IQFVAGKEST QEEFFHTFNS LYEAHKQIVL
     TSDRPPKEIQ TLEDRLRTRF EWGLLADVQP PDFETRLAII KRKAELLGIK LPDEVSEFIA
     NRLKNNIRQL EGAVKKIKAY NLLNGLAPSV ATAQEAIKDI LNDNQPVPVT VQRIIDEVAR
     TYNVSPADIR GKMRSGNISS ARQIAMYIVR EITQLSTTNI GDEFGHRDHA TVVYAIQKVE
     KDMKSNARLK ATIEDIIKNI QAS
//
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