ID A0A078KMQ0_9FIRM Unreviewed; 296 AA.
AC A0A078KMQ0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CDZ25031.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:CDZ25031.1};
GN Name=garR {ECO:0000313|EMBL:CDZ25031.1};
GN ORFNames=CCDG5_1939 {ECO:0000313|EMBL:CDZ25031.1};
OS [Clostridium] cellulosi.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillospiraceae incertae sedis.
OX NCBI_TaxID=29343 {ECO:0000313|EMBL:CDZ25031.1, ECO:0000313|Proteomes:UP000032431};
RN [1] {ECO:0000313|Proteomes:UP000032431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG5 {ECO:0000313|Proteomes:UP000032431};
RA Wibberg D.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LM995447; CDZ25031.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A078KMQ0; -.
DR STRING; 29343.CCDG5_1939; -.
DR KEGG; ccel:CCDG5_1939; -.
DR PATRIC; fig|29343.3.peg.2035; -.
DR HOGENOM; CLU_035117_1_1_9; -.
DR Proteomes; UP000032431; Chromosome.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060:SF3; 2-HYDROXY-3-OXOPROPIONATE REDUCTASE; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CDZ25031.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032431}.
FT DOMAIN 4..163
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 296 AA; 31260 MW; D65D3ED0C3CBC752 CRC64;
MNKKIGFIGL GIMGKPMSKN LIKAGYSLVV YDINPDAMEE VAKCGAEKGT SPKDVAEKCD
IVITMLPNSP HVKQVVLGEN GVLEGARPGM ILIDSSSIAP LVSKEIAEKV KEKGVLMLDA
PVSGGEPKAI DGTLSFMVGG DEEVFAKVED ILKAMGSSVV LVGEIGSGNV TKLANQIIVA
LNIAAMSEAF VLATKAGVDP EKVYKAIRGG LAGSTVLDAK VPMVLARNFK PGFRIDLHIK
DLMNALDTGH GVGVPLPLTS QVMEILQALK ADQKEKQDHS GIVQFYEKLA GIEVKK
//
