ID A0A078L5K3_9GAMM Unreviewed; 1921 AA.
AC A0A078L5K3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=BN59_03531 {ECO:0000313|EMBL:CDZ79213.1};
OS Legionella massiliensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1034943 {ECO:0000313|EMBL:CDZ79213.1, ECO:0000313|Proteomes:UP000044071};
RN [1] {ECO:0000313|EMBL:CDZ79213.1, ECO:0000313|Proteomes:UP000044071}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Urmite Genomes Urmite Genomes;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CCSB01000004; CDZ79213.1; -; Genomic_DNA.
DR RefSeq; WP_044012393.1; NZ_CCVW01000004.1.
DR STRING; 1034943.BN59_03531; -.
DR eggNOG; COG2373; Bacteria.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000044071; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000044071};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1058..1197
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1263..1355
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1921 AA; 211527 MW; C768EB8E0025C23F CRC64;
MNKSIFSQAI AKIGSIFSLV FGRIRWNSPP WAAHLHSKAK SSPLTFWTST GVLIALLAAL
GYGYNWYKNL PKPQLIEASI TAPKITPLAE EMVPDTLSIS FGNSSEEEFV NQSVAPLNLI
GKEVTKGIEL TPAIPGKWVW DSDSSLTFTP DEDWPAGQTY KIHFAKDAFA ATAQMASYNY
EFSTVPFEGK ISEFKFYQDP VNPMLRQAVA TVSFNFPVDS ASLEANTNLM LQAFKFGKLD
LKAKHYQFTI DYDEYKRTAY IHSENISLPE VSLYLILNIG KGVKSSTGSA KLAADLSQNL
LIPDSSNYLK IGSAAASIIR NDQDRPEQIL TVESTLGVTE PEINKSLHVY LLPQNYPATA
TEAEKTNYEW QNPGEVTSNI LALAKPLTTQ ALPSDRNYAT LHSYKFNAQS PQYIYLKIDK
GMRGFGDFVL SNDYTAIIKV PEFPKEIGFL HKGALLALGG EKKLSVLVRG LPAVKFNFAR
VLPENVNQLV TQTQGDFNNP YFINQSFNQQ NIAEIFSEVQ QFNASDLTQQ QYTALDFAKY
LSATANSGGP QGLFLLQATG WDADKNEALD VNASRLVLIT DLGLVVKDNN DGSHDVFVQS
ITQGTPVANA TLTILGKNGL GVLTRTTDAQ GRANFPSLKD FVDEREPTVY LASLGSDVSF
MPYNKANRQL NYSRYDTGGL YSSNQELNSL SAYLFSDRGI YRPGDTAHIA MIVKQAYAKS
QPPGLPLELT ITDPRGTTIK DQKFTLDESG FLSLDFATTD LSPTGQYIVS LYIVKDSRPY
SLLGSTTIKV ADFQPDRMRI SSSFSQEQKQ GWISPTDLKA KVELWNLYGA PATDRTVSAK
ILLAPKRVQF SKYPDYIFAD PLQDPNKPAK VFTDTLADSK TDDKGQAQFD LHLERFDKAT
YQLTFFAEGF EADGGRSVAA QSTALVSPLP YFIGYKPDGD LAYIKQNGQR SVNFIAVNPQ
LAQLKIDGLK IQLVSLHPVT TLVKASDGTY QYQSIIQSTV VDTKPFTINE QGTVYNLPAQ
QIGDFAVNIL DSSNNELSQF KFSVVGTSQQ PLAKNAELGI KLDKEEYKAG EDIELQITAP
YTGAGLITIE RDKVYAVQWF KADSTSSVQK IHIPDDFQGN GYVNVTFVRN WDSPEIFISP
LSYSIAPFAV DHDNQAVHID LTTPKLALPG ETFKIGYKSD KPGKIVVFAV DEGILQVANY
QTPDPLAFFF QKHALEVITE QTVDQILPKF IQDRELSAVG GDGGEELLAS HLNPFKRKTD
LPVVYWSGII DTDATERELS YQIPDYFNGT LRVMAVAVAS DAVGATEKKS EIRGNFVINP
NAPTFVAPGD EFEISVSIAN NVKGSGDNAP VTVQLTSTAG VEIIGDSTEK VEIAEGKEKT
LHFKLRATED LGSTTLNFVA STADKSAKMD ATLSVRPATA FITSIISGST QSAKETLSPE
RSLYPEYRKV EAALSSSPLI LVAGLQRYLE GFPYGCTEQL TSEALPLLAM SGQSWFASDT
KAINDKIAAT VQMLGQRQMS NGGFSYWPGL GDNSSNTFAS VYAMQFLTEA RLQNYDIPAD
LFSAGLSFLR DLAGQTPTDM DKARIQAYAI YVLTRNEIVT TNYLTNLQLY LDKDQQQKWQ
EEITGAYIAA TYQLLQSSGE ANRLITKYKP QVKPVNATDF YDANIADAQY LYLVARHFPG
RLPAIGDKLV MNLVKAINSS ELNTVLSGYS SLALSAYGHA NPPSSDSVFS IEEIFADSKV
KTLTALDNSF ENVAIDEHVK QINFINPNSQ TVFYQLSQAG FDKELPTKAQ SEGVEIYREY
RDSKGNVINS TTLGTEIEVH IQVRSLANPY LSNIAIVDLL PGGFEVVRDS VHLDNIDYAD
VREDRVVFFT GLDTSAREIV YRIKAINTGH YTVPAIIAES MYDPNVRANS AAGGIEVRER
S
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