ID   A0A078LUM3_9PSED        Unreviewed;       832 AA.
AC   A0A078LUM3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=BN1079_02276 {ECO:0000313|EMBL:CDZ94945.1};
OS   Pseudomonas saudiphocaensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1499686 {ECO:0000313|EMBL:CDZ94945.1, ECO:0000313|Proteomes:UP000053902};
RN   [1] {ECO:0000313|EMBL:CDZ94945.1, ECO:0000313|Proteomes:UP000053902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20_BN {ECO:0000313|EMBL:CDZ94945.1,
RC   ECO:0000313|Proteomes:UP000053902};
RA   Urmite Genomes Urmite Genomes;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; CCSF01000001; CDZ94945.1; -; Genomic_DNA.
DR   RefSeq; WP_037024371.1; NZ_CCSF01000001.1.
DR   AlphaFoldDB; A0A078LUM3; -.
DR   STRING; 1499686.BN1079_02276; -.
DR   eggNOG; COG0286; Bacteria.
DR   HOGENOM; CLU_013049_4_0_6; -.
DR   OrthoDB; 9784823at2; -.
DR   Proteomes; UP000053902; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053902};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          8..149
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          163..488
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   REGION          698..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        708..722
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   832 AA;  93245 MW;  4DD4037F469A1B4D CRC64;
     MPLTLQQLER HLFKAADILR GKMDASEFKE YIFGMLFLKR CSDVFEERYE QVIADELKAG
     KSKAEAHITA ENPRWYKRDG NFWVPSQSRF KHLVNEAHIN VGDLLNKALS GIEENNSSLE
     GVLEHIDFTR KVGQSKIPDQ KLRQLITHFG DVRLRNSDFE FPDLLGAAYE YLIAEFADSA
     GKKGGEFYTP RSVVRLMVHL LKPTLAHDIY DPCCGSGGML IAAKEYIDEH GEDGRKANLF
     GQEFNGTVWS IAQMNMLLHG ISNAWLENED TLADPRHIEG GELRRFDRIL TNPPFSINWG
     HTEKNADGSL AWNPTFREER FRFGEVPLGS KKADLMFLQH MLAVTRDEGM VATVLPHGVL
     FRGGEEKAIR AGIIEADLLE AVIGLPANLF YGTGIPACIL ILRQQKQEGA NRVSAKPAER
     QGKVLFINAD REYFEGRAQN FLLPEHIEKI TTAYEEFRQI DGLSDVIDIA TLRDNDYNLN
     IRRYVDNAPP PESHDVRAHL LGGVPKAEVQ AKAALFSAHG LDPLDLFAER DAQYFDFKPE
     LTQRADLKAA IEGNPGLQLK EASIRAAFEA WWSEHSPRIT ALAGKLDDSA ALVSLRGELL
     ASFSETLERI GLLDPFQVRG IVAGFWYQSK YDFLGLMARG SSGVMDAWRT SIVTAMEDKA
     SKHSPLEHKL VKFLLNDFVA GLAELEAKKA ELESQLKAAT PAKGEDGDEA ESEAETSDAE
     ESAVDEAQLK AWKAELAKVK KQLKTQKDNF ATHLNQAVDG LDEQQAGELL LTILHNDMQA
     IVERYIAAQR KQIVAAFENW WDKYRVTLNE IEHKRDAAAE ALQGFLKGLG YV
//