ID   A0A081BIX6_9LACO        Unreviewed;       285 AA.
AC   A0A081BIX6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Aldehyde oxidoreductase {ECO:0000313|EMBL:GAK47994.1};
GN   ORFNames=LOSG293_160370 {ECO:0000313|EMBL:GAK47994.1};
OS   Secundilactobacillus oryzae JCM 18671.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Secundilactobacillus.
OX   NCBI_TaxID=1291743 {ECO:0000313|EMBL:GAK47994.1, ECO:0000313|Proteomes:UP000028700};
RN   [1] {ECO:0000313|EMBL:GAK47994.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG293 {ECO:0000313|EMBL:GAK47994.1};
RA   Tanizawa Y., Fujisawa T., Mochizuki T., Kaminuma E., Nakamura Y., Tohno M.;
RT   "Draft Genome Sequence of Lactobacillus oryzae Strain SG293T.";
RL   Genome Announc. 2:e00861-14(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAK47994.1}.
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DR   EMBL; BBJM01000016; GAK47994.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A081BIX6; -.
DR   STRING; 1291743.LOSG293_160370; -.
DR   eggNOG; COG0656; Bacteria.
DR   Proteomes; UP000028700; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   4: Predicted;
FT   DOMAIN          18..271
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        58
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         117
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            84
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   285 AA;  31971 MW;  C163BE135ED5435A CRC64;
     MEAIEMKQLN FKGESVSELG IGTWNIGEGD ARQSSQEITA IQYGLEHGIN FIDTAEMYGE
     GKSETLVGQA IQPYDRDKLF ITSKFYPFHA TPSLMRASLT KSLQRLKIDY LDLYLLHWRG
     NTPLVETVQG MYELQAEGLI KHWGVSNFDT SDLQELIELP HGKDVFANED LYNLRSRGIE
     FDLLPWQAEN NIPFIGYSPF GSGNGKGIDS PELRQIAQER QVSVQAILLA WVTRHHDVLS
     IPKASQVEHV TANIAATEIK LTAEELARLD QDFPAPIGKQ ALDVI
//