ID A0A081G1Q8_9GAMM Unreviewed; 799 AA.
AC A0A081G1Q8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=ADIMK_1166 {ECO:0000313|EMBL:KEA64713.1};
OS Marinobacterium lacunae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Marinobacterium.
OX NCBI_TaxID=1232683 {ECO:0000313|EMBL:KEA64713.1, ECO:0000313|Proteomes:UP000028252};
RN [1] {ECO:0000313|EMBL:KEA64713.1, ECO:0000313|Proteomes:UP000028252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK27 {ECO:0000313|EMBL:KEA64713.1,
RC ECO:0000313|Proteomes:UP000028252};
RA Singh A., Pinnaka A.K.;
RT "Marinobacterium kochiensis sp. nov., isolated from sediment sample
RT collected from Kochi backwaters in Kerala, India.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEA64713.1}.
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DR EMBL; JMQN01000015; KEA64713.1; -; Genomic_DNA.
DR RefSeq; WP_036184869.1; NZ_JMQN01000015.1.
DR AlphaFoldDB; A0A081G1Q8; -.
DR STRING; 1232683.ADIMK_1166; -.
DR PATRIC; fig|1232683.4.peg.1156; -.
DR eggNOG; COG1067; Bacteria.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000028252; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122,
KW ECO:0000313|EMBL:KEA64713.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000028252};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 564..759
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT COILED 201..235
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 799 AA; 88976 MW; 2FD555E2A6C7EA72 CRC64;
MALKPLDSDK LYHRCDLSDF GFTSTNDLTP DLSALGQQRA MDALQFAVGM HHDGYNLFVS
GSTGVGRREL VSRMINERAK QGEAPQDWVY VHNFERAHEP CMLCLPKGAG QGLRQDMQQL
IERLLIQIPA TFKSDEYRNR VQEISDEFEQ REESQFQALG EKAHEEQITL MRTPSGYTLG
PLREGKLMTP DQFKALPEAE QTRIKAALEQ LNAELTALVR ELPKLQQEHR EAIRALDDDI
THSVIDPALS GLRQKYGTES ALLEFLDQVH QDMIENVDDF FAQDKDENAK TPLHKLARSD
TFRRYRINVL VSHDHNGGSP VVVEDIPSYQ NLVGRIEYQA HFGTLSTDFS LIQPGALHRA
NGGYLIVDAQ KLLSYPFAWE GLKRALRNRE IRIDPLEKMY GISGTRSLEA EPMPLKLKVI
LIGERRLYYL LKAYDPEFST LFKVYADFNE QLDRSRGNLE GYLGLITQLV QEEGLAPFAL
SGIERVIEQS SRRVDDSTKL SLNRGQLIDL LREASYCATR AGSSQVKSEH VSQALKMART
RSAQYSELMQ EQIERGTIMV ATEGSAVGQA NGLSVFQLGD QRFGKPARIS ATARLGGGKV
IDIERETELG GPIHTKGVMI LANCIGARYA RNSPLSLHAS LVFEQSYGMV DGDSASALEL
CVLLSAISGL PIKQSLAVTG SINQRGEIQA IGGVNEKIEG FFELCKNRGL TGDQGVVIPA
TNVDHLILDQ AVVQACEKGE FHIYAVKELD ELISLLFDRK PGKADEDGRY PPASVNGCVQ
QQLLDWTEQA RKLSGKSDN
//
