ID A0A081PGL0_9SPHI Unreviewed; 1856 AA.
AC A0A081PGL0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:KEQ29833.1};
GN ORFNames=N180_20410 {ECO:0000313|EMBL:KEQ29833.1};
OS Pedobacter antarcticus 4BY.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=1358423 {ECO:0000313|EMBL:KEQ29833.1, ECO:0000313|Proteomes:UP000028007};
RN [1] {ECO:0000313|EMBL:KEQ29833.1, ECO:0000313|Proteomes:UP000028007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4BY {ECO:0000313|EMBL:KEQ29833.1,
RC ECO:0000313|Proteomes:UP000028007};
RA Shivaji S., Ray M.K., Rao N.S., Saiserr L., Jagannadham M.V., Kumar G.S.,
RA Reddy G., Bhargava P.M.;
RT "Sphingobacterium antarcticus sp. nov. a Psychrotrophic Bacterium from the
RT Soils of Schirmacher Oasis, Antarctica.";
RL Int. J. Syst. Bacteriol. 42:102-106(1992).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEQ29833.1}.
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DR EMBL; JNFF01000061; KEQ29833.1; -; Genomic_DNA.
DR RefSeq; WP_037441132.1; NZ_JNFF01000061.1.
DR eggNOG; COG2373; Bacteria.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000028007; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028007};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 992..1134
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1198..1287
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1856 AA; 206277 MW; 172F6DF741820F11 CRC64;
MKTPIPQKNK IIILSIVAAL VIGVAAFFIF RKDKTNENKQ AYAKYIEAYT SGVVSKKSTI
RIQLAGQVNT IGEIGKPDER KLFSFSPSLK GKTFWIDAQT IEFRPDEELE SGENYKVSFK
LDKITPTEKG LEEFDFGFRV IQPGMAISQE GLVSQNNTSL NYMKLKGEIS TADQEDPKLI
EHALELEFPQ KLKIKWQHNA AANTSTFQID SIRKTGNEQK FEIKWSGKPI NADQKGKIEL
PVPALGVFKV MDVRAVQQQE DYALVQFSEP VGIGQDLNGL ISLSNTGELK YTIDGSQVKV
YSPAALLGNY TLTANKGVVN SNEKTLQSAV SANLLFENKM PSVVIAGSGT ILPNSGKLVL
PFEATNLKTV DLTIVKVYEN NLPQFFQTNN YKDAGELRRV GKPLLQKKIR LDEDKTLNLH
KKNRFVLDLD DIIKTEPGAM YRITLSFRQS YNLLNCNDAG NSENASDEDQ DYGYYGQKID
EDDDFWANYD RYYSGGYNWN DKDNPCTPSY YTNDKWASRN LLVSNIGLVA KRGNDNSMLV
VATDLLTTKG LSGTTLELLD YQRQVILSTK TDGEGMATFE LKRKPFLLIA KNGSERAYLK
LDDGNSLPLS RFDVGGEQVQ NGLKGLIYGE RGVWRPGDSL FLSFILEDKL KKLPPSYPVT
FELYNPQGQL YKKSVSASPI NGFYNFKTST ENGSPTGNWN VKVKAGGATF QKTLKVETVM
PNRLKIDFNI GNRTYLGTGN QTPATLTASW LFGSPGKDLK AKVDVNLNPM KTTFKGFEGY
QFDNPTASYP SEIKTIFEGR LNGEGKVSVN TNLNENNVAP GMLKANFTTK VFEAGGNFSI
DNFSIPYHVF QNYYGIKAPQ GEKLSGMLVT GKDHIFDLVN VDRNGKMTAG NKVVQLELYK
VQWRWWWEQD DQNSFANFTQ NEYNKLVSKE TINLENGKGK WKLRVNEPEW GRYLILVRDL
NGGHVTGQSV YIDWPGWAQR EQGNNPTEAS MLSFTANKTK YNVGEDIVLT IPTGKNGRAL
ISIENGSKVL KTFWTDTKAG QTQFKFKADK EMAPNVFANI TLLQPHAQTI NDLPIRMYGA
IPLFIEDKQT TLNPVITMPD KIRPETQSSI KISEKSGKAM TYTIALVDEG LLDLTRFKTP
DPHAVFYARE GLGVKTWDLF DQVLGAWGGN LERILSIGGD GNLNRNLNPA KANRFNAVVK
YMGPFKLGKG ETQTHQFKLP QYIGAVRAMV IAGQDGAYGN AEKSVQVKKP LMVLATLPRI
IGPGERFTLP VTVFATENNL KQVNVKLETQ RLNVIGTKDK TLSFAKPGEQ MAYYEVTVPQ
QTGIAKVKIT VQSGTEKASY DLEMDIRNPN PYITQVISTT IEPGATWTSP YTPIGISGTN
SGSLEISGIP AINLKKRMAF LIQYPHGCVE QTTSAVFPQL YLDKLSPLST QEKTKTDQNI
RAGINKLRSH QTTDGGLAYW PGMPSADEWG TNYAAHFLVE AQQAGYTLPV GMLDEVLRYL
KNKATAWVPN SNNFYGGDLS QSYRLYVLAL ARKPEMAAMN RLRAFEYLSV TAKWRLAAAY
QLAGQASAAN ALIKGLNIDI QPYQQLGGTY GSAIRDEAMI LETLTLMGQK GRATQLLQGI
AAKLGQDEWY STQTTAYSLL AIAKFCGANK GGNIQYNYLI DGKKGSYNSS GFLSSIPLSF
KGANASVTNN GKSLLFARLI LDGQPAPGQY TAKTQDPNIL DMKVSYKLLN GKPLNPAKLA
QGLDFYAEVV IKNPGKMGLY EQMALTQIFP SGWEIINTRL NDNEGILASS PYTYQDIRDD
RVLTYFNLRE NETVTYKVLL NAAYLGRYYL SAVSAEAMYN NQISAVENGM WVEVTP
//
