ID A0A084VJC5_ANOSI Unreviewed; 551 AA.
AC A0A084VJC5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=AGAP000018-PA-like protein {ECO:0000313|EMBL:KFB38069.1};
GN ORFNames=ZHAS_00005359 {ECO:0000313|EMBL:KFB38069.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB38069.1};
RN [1] {ECO:0000313|EMBL:KFB38069.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC005359-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00879}.
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DR EMBL; ATLV01013513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524867; KFB38069.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VJC5; -.
DR STRING; 74873.A0A084VJC5; -.
DR EnsemblMetazoa; ASIC005359-RA; ASIC005359-PA; ASIC005359.
DR VEuPathDB; VectorBase:ASIC005359; -.
DR VEuPathDB; VectorBase:ASIS018586; -.
DR OMA; DECATIK; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR CDD; cd08693; C2_PI3K_class_I_beta_delta; 1.
DR Gene3D; 3.10.20.770; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR PANTHER; PTHR10048:SF118; PI-3 KINASE; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 1..77
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 144..309
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 338..515
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT REGION 112..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 63389 MW; EF93E9B97E90CA40 CRC64;
MQVTVKVPCR ATPEEVLKRI LEKKQISAKA RNDNSADFIL KVCGREEYIY GSHPIIDFQY
VQDCLSRDEI PTFVPRLVRT VEVFKNDIYD AREDFSQWTA VGSNALAIAG GGPKAKLQTQ
QQQQSQQQQH PTLRKPKHLT SWEVNTKLSC TVHEIQNLNC DANRNVEVGI QLGLFHGGKS
LCKTERTRMV LINKTHASWN QRIEFDINVS NVPRMARLCL VVYENIRTAK GIGIRARRTK
DGLINPIAWV NTMVFDYKSQ LKTDSATLYT WTYAEDAQSD DILHPLGTVE PNPKRDETPS
VLLSFGSYDY DGQIIVYPSE EELLAHAARM SHRNEHLNRE SAEDTRSIKE ILSVYMYNDR
LNDIHEQDRN AIWAKRRDCL QQMPQGLPCL LYCVEWNNRD EVAEIVSLLQ EWPKLLVERA
LELLDYAYAD KYVRRYAVAC LSTIEDDELL LYLLQLVQAL KHESYLNCDL VGFLLKRALH
NQHIGHFIFW HLRSELGVPS VQVRFGLILE AYLKGSPEHV IVLLRQTQCL HQLKICSDTV
KKGSKERAGR C
//