ID A0A084VJI3_ANOSI Unreviewed; 374 AA.
AC A0A084VJI3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
GN ORFNames=ZHAS_00005402 {ECO:0000313|EMBL:KFB38127.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB38127.1};
RN [1] {ECO:0000313|EMBL:KFB38127.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC005402-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC Nucleus {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; ATLV01013581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524868; KFB38127.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VJI3; -.
DR STRING; 74873.A0A084VJI3; -.
DR EnsemblMetazoa; ASIC005402-RA; ASIC005402-PA; ASIC005402.
DR VEuPathDB; VectorBase:ASIC005402; -.
DR VEuPathDB; VectorBase:ASIS011653; -.
DR OMA; MIIVFNK; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd17870; GPN1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365059};
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT REGION 319..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 42239 MW; 00A43D2CBB6EE75D CRC64;
MASVPEQKAG SSKPECGRPV CLIVLGMAGS GKTTFVKKLA QYRHANGSLP YLINLDPACR
ETPYPVNVDI RDTIKYKEVM NRYKLGPNGA IVTALNLFST KFGKVTELIE KAKDKHQYCV
LDTPGQIEVF TWSASGTIIT EALATAFPTV VVYVMDIVRS TSPTTFMSNM LYACSILYKS
RLPFVIVMNK IDVQECEFAM QWMQDFEAFQ EALENETAYV SNLTRTMSLT LDEFYQNLKS
CGVSSVTGIG FARFFELVSE AVKEYDSDYK QEYEKLRIEK EKLKESELEK LSQTKRGDIG
EEIPLGNDSG MPTEHNERIY LRHPANESSD DDEGQECDGA VVTAGDDEVE DMNFNSFIEQ
HRRQQNEKQL KQNK
//
