ID A0A084VMX5_ANOSI Unreviewed; 1897 AA.
AC A0A084VMX5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=AGAP009180-PA-like protein {ECO:0000313|EMBL:KFB39319.1};
GN ORFNames=ZHAS_00006676 {ECO:0000313|EMBL:KFB39319.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EnsemblMetazoa:ASIC006676-PA, ECO:0000313|Proteomes:UP000030765};
RN [1] {ECO:0000313|EMBL:KFB39319.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC006676-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ATLV01014632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE524975; KFB39319.1; -; Genomic_DNA.
DR STRING; 74873.A0A084VMX5; -.
DR EnsemblMetazoa; ASIC006676-RA; ASIC006676-PA; ASIC006676.
DR VEuPathDB; VectorBase:ASIC006676; -.
DR VEuPathDB; VectorBase:ASIS007482; -.
DR VEuPathDB; VectorBase:ASIS014494; -.
DR VEuPathDB; VectorBase:ASIS018574; -.
DR OMA; IVPGNNY; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF341; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 208..395
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 440..543
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 592..744
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 782..1019
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1032..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1110..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1591..1666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1680..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1784..1897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1204
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1385
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1528..1557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1625
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1663
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1813..1868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1876..1897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1897 AA; 207693 MW; 2BAC0A59FD24EF21 CRC64;
MFSGSSHVSI TDAADYDFEN AENAAKWRGL FITSLRKVLE QVHPSLQAKE DALLYVESLC
LRLLATLCAK PPPHTVMDVE ERISRTFPNP IDRWALGEAR ETIDKSKKKK PVLPVDRVHT
LLQKEVLQYK IDSSVSLFLV AVLEYISADI LKLAGYYVKN IRHIEITRED IEVAMCADKV
LMDMFYQGES SNSMAPSPLP PTPRASLSYE EVVKELIHDE KQYQRDLHMI IRVFREELVK
IVKDPKELDL IFSNIIDIYE VSVTLLGSLE DVIEMSQEQT PPCIGSCFEE LAEAAEFDVY
AKYAKDITSV AAKEALANLL ARPEVASSLM SAGHGFKEAV KFYLPKLLLG PIGHAQLYLD
YIKVLLQLSP SQEDKESFEQ VQGLLKPLQC ELQSISSLLP KEYFTRVNSR ARRQSAIEKT
RDLQNTVEHW DKDVGQCCNE FIREDTLAKL SSGKRQTERK VFLFDGLLVL CKARRQIVPG
NNYDYRQKER FFMRKVEIID RPDTDELKHA FEISPREQQS VVLITKNAQH KNDWMADLIM
LNTKSMLERI LDSILLDIEK KHPLKLPSPG IYKFAVPDSP SNIVLEEREG TGVPLIKGAT
LCKLIERLTY HIYADPMFVR TFLTTYRSFC SPKELLQLLV ERFDIPDPGV VYDPANDKDG
LGSDTDKFHK NSQREDWKRY KKEYVQPVQF RVLNVLRHWV DHHFYDFERD LELLESLERF
LDTVRGKSMR KWVDSVMKIV QRKNDSEDNH RQITFAFGHS PPAIEHHLPL NSENEFNLLM
LHPLELARQL TLLEFEMYKN VKPSELVGSV WTGKDKETTS PNLLRIMHHT TNFTRWIEKS
IIEAENFDER VAMASRAIEV MMVLQDLNNF NGVLSIVSAF QGAAVHRLRL TLEEIPKRHQ
QVLAECRELN NSHFKKYQEK LRSINPPCVP FFGMYLTNIL HIEEGNPDFL PNTELINFSK
RRRVAEITGE IQQYQNQPYC LKVDPNIRHF LENLDPFKGM SITEIQNYLY DESKRIEPKN
CRQPLKCPRK WPDISLKSPG IKPSSRRNNS SANSSMTLPG TLPYSKTSLL TNSDTGEQSP
PASSSSSVHD YSIFASVNIH STSGASSLSS LYYQQQQQQN QQHPGLHHGQ QAHHGVQYPQ
QSSSHHYGFY QGHPGGSTTL GPGSGSSGSA HYHSTYHHHS QGHHNHHHHQ QQQHHHHHHH
HHPTFSQSIA NLTTAGGDSQ MAPEIPRRSD SIILTGTNAA NHLIAGSLSE GSGSYNGGKH
LSTSYYPSAS LSTLSSSLAS SSVVGGGSVV GGSAGVGAST YSIGGSLYSG SSSEASGYGT
ASSVTSSSAA SIVSMSHNDG VTQLQQPPPP GTAGAGHPPD IPPAISPRTD KSQPLPPPPP
PPLHGTGAGS NTSSTSSNST GTIVANTTTV TTAIANSTSS NFSHSASYAI KNQNCDSSHA
APGGVAGNSI GSGSTGVVPP PLPPLSNNSS AGRPSSCENS PVYPSSPKIH LSYNHAGGAG
ALPSTETTPA AAPCPHHSKH CQHHTQHHSA APDGSGFTWQ PYSSSPGQQQ QQQGGDGIGA
ASPCPACGNA CHLCNSNSDV GGGGGGAGLP NNADLGPIPH SPHVNVPNTH NVLPPMPPPP
IPPRVKRKES STESSQSSQI RQAPDAPTLP PRDVSPPPLP PRTHTQSHYQ FGVASQGGST
VLLNYTQPPS ANHPGKDEST SSSSSSSTLT RDNLNQHNHH QHQVAGGNGN PNSASTSSSL
EQRLLMLPHT STIMMRRNSA MDRASKENIP NLASSSSLSS GLSAIVGGGG GTPGSGATMT
PGPPVIPSAN PGGGGSVGNS PSAVKNKSVQ NSPISSAGGQ RESSHQPQLQ GNVLCRRAST
NISPRFSPGE TTPKLPPKPK QSNLNSDRTM FPYPSTN
//