ID A0A084VVL0_ANOSI Unreviewed; 896 AA.
AC A0A084VVL0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=AGAP000255-PA-like protein {ECO:0000313|EMBL:KFB42004.1};
GN ORFNames=ZHAS_00009581 {ECO:0000313|EMBL:KFB42004.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB42004.1};
RN [1] {ECO:0000313|EMBL:KFB42004.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC009581-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; ATLV01017194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01017195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525157; KFB42004.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084VVL0; -.
DR STRING; 74873.A0A084VVL0; -.
DR EnsemblMetazoa; ASIC009581-RA; ASIC009581-PA; ASIC009581.
DR VEuPathDB; VectorBase:ASIC009581; -.
DR VEuPathDB; VectorBase:ASIS009884; -.
DR OMA; XYARFEA; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR015143; L27_1.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF51; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF09058; L27_1; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..64
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 150..237
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 247..339
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 436..517
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 547..617
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 706..881
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 93..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 99825 MW; 756385A792CCC5A1 CRC64;
MPVKKQEAHR ALELLEDYHS RLSTPQDHAL RSAIERVIRI FKSRLFQALL DIQEFYELTL
LDDSKTVHQK TIETLLIASK WEHDNVVKSN ETNRIQQQEQ PQQKQPQPQQ QTHRQSQHLP
EVEKQPFIEL PSSELSTSKL NGNSPWEYDE ISLVRGTTGL GFSIAGGTDN PHINLDASIY
ITKVIPGGAA HADGRLQVND CIVAVNDVRV VNVTHGQAVD ALKKAGDQVT LHIRRKKPPV
QAPKLEEIEL LKGNKGLGFS IAGGIGNQHI PGDNGIYVTK IMEGGAAHID GRLAVGDKLI
AVLTPTAGER NLENVVHEEA VATLKAITNR ATLVVQKTNI LQALANSISN LNSLSTNAMN
KVGVSMVDHA GDVGNGTGES RPEGDAEFST TRSHSPVFVL ENTSSRYASS NVLETGMPIG
TPKAVSSEDI TRLPRTIVIR KGASGLGFNI VGGEDGQGIY VSYVLAGGAA DLGGELKRGD
QLLSVNGTSL TDASHEDAAQ ALKNAGGTVT LEVQYRPEDY NRFEQRIQEL KQAVATGTGT
LLRTSQKRTL YVRALFDYDP NKDDGLPTRG LQFRHGDILH VTNASDDEWW QARRVIGDDE
EESIGIVPSK RRWERKQRAR DRSVKFQGHA SPNNNNLEKV ATLDRKKKNF SFSRRFPFMK
SKDEKNEDGS DQEPFMLCYT QEDANAEAEE SILSYESVHR LQINYTRPVI ILGPLKDRIN
DDLISEYPNK FGSCVPHTTR PKRDYEVDGR DYHFIASREQ MERDIQNHLF IEAGQYNDNL
YGTSVASVRE VAEKGKHCIL DVSGNAIKRL QVAQLYPISI FIKPMSIESI MEMNRRMTEE
QAKKTYERTL KMEHEFGEYF TAIVQGETTE EIYGKVKNVI WSQGGPTIWV PTKESL
//
