ID A0A084VZH5_ANOSI Unreviewed; 965 AA.
AC A0A084VZH5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0000259|PROSITE:PS00623, ECO:0000259|PROSITE:PS00624};
GN ORFNames=ZHAS_00011169 {ECO:0000313|EMBL:KFB43369.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EMBL:KFB43369.1};
RN [1] {ECO:0000313|EMBL:KFB43369.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC011169-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR EMBL; ATLV01018820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01018821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01018822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01018823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ATLV01018824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525249; KFB43369.1; -; Genomic_DNA.
DR STRING; 74873.A0A084VZH5; -.
DR EnsemblMetazoa; ASIC011169-RA; ASIC011169-PA; ASIC011169.
DR VEuPathDB; VectorBase:ASIC011169; -.
DR VEuPathDB; VectorBase:ASIS005104; -.
DR VEuPathDB; VectorBase:ASIS020835; -.
DR OMA; NINRRNW; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11552:SF208; GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF00151; Lipase; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU003968};
KW Flavoprotein {ECO:0000256|RuleBase:RU003968};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 484..507
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 660..674
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
SQ SEQUENCE 965 AA; 106817 MW; DBE796BEA6A05B25 CRC64;
MGVNRCXXXX XXXXSIEALL KRREPRLKPN EVEFVLYTRD DDDDDGQRLG PFTEEYDFEG
TNFRSDRPTR VIVHGWLNNK NSPFVEQLRH AYIRRWDYNV IVVDWSSCAK LWNYVRAVKC
VPVVGKSLAF LLDELHRRRE LQLESVYIVG HSLGAHVAGI AGKRVQYGPI HTIVALDPAL
PLFSMHAPGN RINAQDARYV EVWHTNGGWF GFLRPIGTAD VYPNGGTHQP GCGLPVAGLC
SHSRAWELYV ESLVEPEENL LAHRVDSLEE INNSESQKGV GVIPFGQRVK MGGEPSSAGS
ARGLYFIERI VPHTTFQSVG QCVSICRSDR MAVNVRWSSV TACRVVLLVA LCAWATVPGT
GGQRGVPGTG GGGGGWLDKF NKLLSRSKQR NATEDNEVLD ADEYDFVIVG GGTAGMVLAS
RLSENRDWRV LLLEAGQYGT KLFNIPIGFQ LAVLSDSYNW RLLSEKQTNA CWGTIDGRCP
VDIGKGVGGS TLVNGLIYSR GNRDDYDRWS AAGNDGWSYD EVLPYFRKAE KAIGEGLDRD
FRSNSGPLRI ERSSFRSEHA RIYMEAAKAA GYNEVDYNGR TQFGIAPVQA TMTKGQRLTA
YNAYLQPVQK KRTNLKTLTG ALVTKILIDP DTKQTEGVQF TRNGQQYEVR ARKEVILSAG
AILSPQLLMV SGVGPREHLE SVGVPVLVDL PVGESLYDHL GFSGLQIVMN GTGFFAPGDI
PTFENFYEYL KGKGVLTVPA AVELVTYPNL TLAGRRGPTL ELMNLISSFA VDKGTTAKQS
VRMRDDVYEA VYRPLETQNH FTIIVQNLHP LSRGSVRLRS GNPAQPPIVD PNYLAEELDV
DVVLEGIREV QRVLETDELR RYGATVWTSG RLPNCAEHEP DSDDYWRCAV RTVSFSLTHF
MGSCKMGPPT DADAVVAPDL KPYGLERLRV VDASVIPEPV SAHPMAAVYM LAERAADLIR
LEHLP
//
