ID A0A084W6U6_ANOSI Unreviewed; 682 AA.
AC A0A084W6U6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 41.
DE SubName: Full=AGAP010395-PA-like protein {ECO:0000313|EMBL:KFB45940.1};
GN ORFNames=ZHAS_00013905 {ECO:0000313|EMBL:KFB45940.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EnsemblMetazoa:ASIC013905-PA, ECO:0000313|Proteomes:UP000030765};
RN [1] {ECO:0000313|EMBL:KFB45940.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC013905-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR EMBL; ATLV01020953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525310; KFB45940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084W6U6; -.
DR STRING; 74873.A0A084W6U6; -.
DR EnsemblMetazoa; ASIC013905-RA; ASIC013905-PA; ASIC013905.
DR VEuPathDB; VectorBase:ASIC013905; -.
DR VEuPathDB; VectorBase:ASIS004871; -.
DR OMA; ASNCFWA; -.
DR OrthoDB; 142935at2759; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16197; EFh_PEF_CalpC; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF394; CALPAIN-C; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT DOMAIN 18..324
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 553..588
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 260
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 682 AA; 77907 MW; 43A48A8697BF1D63 CRC64;
MTSSYERIKS ECKQKGVLWE DDDFPATQSS VFYHQTPPFT FQWKRPHEIV SNPVFVNDST
AQFDIVPGKM GDRWLVSCLG VLYLSKGLFY RVVPADQNFD KPYYGVFRFR LWWCGEWLEV
LVDDRLPTIN GKLAFLQAQN TNSFWPGLLE KAYAKLHGSY EALKYGTLLD GLADLTGGIT
ESISIKVDSN IIIRPPLLHN LLDTTSIITC TINNGTITQI RNQTEALPNG IHIGINYRLC
SMDKAETIMG DTVQLVRLRN PLAQTLNKAA ANFNGDWSSF SSSWERVTMN ERNRLIEQLD
QGEFWMSFFD MTQTFTHLEC VHLDSDTARD EPQLADKSRR WLMRLYQGAW KRGVTAGGCR
NNPDSFHINP QLQLFLSEKE DVIISVNQHS VLEPKVIGFT VYNLNSVQNI NGCLSKNFFK
KHKSLVNSQY TNSRQISHRC SLDPGRYLIM ATTFEPAEEA SFSVRVLGST IRLALLETQT
MLLLDPFPLL NSNTKILIDS ANNNNNNNGI ACSTAQYEPV FMQLADDQRT LNCFDLQELL
EACLPNDYIR SCASIDVCRQ VVCLMDKTNR GRINFNDFNK FMINLKTWWG VFKMHTKEKS
GILKAERLRD ALFDVGFQLS TDNISILILR YMRRDGTLRL ADFISAILHL TMAFELFKAK
DTNQDGIISM GMSEWIKSVF MC
//
