ID A0A084WDA7_ANOSI Unreviewed; 277 AA.
AC A0A084WDA7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 32.
DE RecName: Full=Gem-associated protein 2 {ECO:0000256|PIRNR:PIRNR038038};
GN ORFNames=ZHAS_00016265 {ECO:0000313|EMBL:KFB48201.1};
OS Anopheles sinensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=74873 {ECO:0000313|EnsemblMetazoa:ASIC016265-PA, ECO:0000313|Proteomes:UP000030765};
RN [1] {ECO:0000313|EMBL:KFB48201.1, ECO:0000313|Proteomes:UP000030765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24438588; DOI=10.1186/1471-2164-15-42;
RA Zhou D., Zhang D., Ding G., Shi L., Hou Q., Ye Y., Xu Y., Zhou H.,
RA Xiong C., Li S., Yu J., Hong S., Yu X., Zou P., Chen C., Chang X., Wang W.,
RA Lv Y., Sun Y., Ma L., Shen B., Zhu C.;
RT "Genome sequence of Anopheles sinensis provides insight into genetics basis
RT of mosquito competence for malaria parasites.";
RL BMC Genomics 15:42-42(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASIC016265-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: The SMN complex catalyzes the assembly of small nuclear
CC ribonucleoproteins (snRNPs), the building blocks of the spliceosome,
CC and thereby plays an important role in the splicing of cellular pre-
CC mRNAs. {ECO:0000256|PIRNR:PIRNR038038}.
CC -!- SUBUNIT: Part of the core SMN complex. {ECO:0000256|PIRNR:PIRNR038038}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the gemin-2 family.
CC {ECO:0000256|ARBA:ARBA00025758, ECO:0000256|PIRNR:PIRNR038038}.
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DR EMBL; ATLV01022979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KE525339; KFB48201.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A084WDA7; -.
DR STRING; 74873.A0A084WDA7; -.
DR EnsemblMetazoa; ASIC016265-RA; ASIC016265-PA; ASIC016265.
DR VEuPathDB; VectorBase:ASIC016265; -.
DR VEuPathDB; VectorBase:ASIS005052; -.
DR OMA; AHSLIWQ; -.
DR OrthoDB; 5390889at2759; -.
DR Proteomes; UP000030765; Unassembled WGS sequence.
DR GO; GO:0032797; C:SMN complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000245; P:spliceosomal complex assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1070; -; 1.
DR InterPro; IPR017364; GEMIN2.
DR InterPro; IPR035426; Gemin2/Brr1.
DR PANTHER; PTHR12794:SF0; GEM-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR12794; GEMIN2; 1.
DR Pfam; PF04938; SIP1; 1.
DR PIRSF; PIRSF038038; SMN_Gemin2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038038};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR038038};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR038038};
KW Reference proteome {ECO:0000313|Proteomes:UP000030765}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 31552 MW; CF7E802C208E1F34 CRC64;
MEVDTIQKPA LAVDPPDENF DPDLIPETGE QYLQKVMYER GKCPVVVVAA KPHNRHNPQK
VLTGLGALPT DDVKNVAPQA LMPTKEWESM QNQKFAELRD IITSYRGSAQ YSENLQRTHV
FLNFDDRKQL HEYCANNLPY VRILLSIPQR NLEMLLEYLH EWLQDTEPTS GQSSQDEPSD
PELCDATSTM TPTGSKEPLR TGCRKDWITQ WIYAILACLI LPLEPYIHSV LRDIAKSCIT
LRNELKQEDE AKVLPLNLLI SIISKNFKQA DLADNVP
//
