ID A0A085MWJ6_9BILA Unreviewed; 1462 AA.
AC A0A085MWJ6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Tr-type G domain-containing protein {ECO:0000259|PROSITE:PS51722};
GN ORFNames=M514_04173 {ECO:0000313|EMBL:KFD61592.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD61592.1};
RN [1] {ECO:0000313|EMBL:KFD61592.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD61592.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR EMBL; KL367618; KFD61592.1; -; Genomic_DNA.
DR MEROPS; M41.A10; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04094; eSelB_III; 1.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR CDD; cd00165; S4; 1.
DR CDD; cd03696; SelB_II; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR049394; eEFSec_C.
DR InterPro; IPR049393; eEFSec_III.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF2; SD01613P; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF21131; eEFSec_4th; 1.
DR Pfam; PF21208; euk_SelB_III; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR Pfam; PF01479; S4; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 788..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..210
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 581..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1427..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 162751 MW; AD9B5F69C95DA66C CRC64;
MTVRDATAAG TPRVLNFNVG ILGHVDSGKT ALAKAISKVA GTAAFDKHPE SRRRGITIDL
GFSCFTVPVT EQMTIRDEQL MNYDVIQVTL VDCPGHSSLF RTVIGCSQIV DMVFLIVDIQ
KGIQPQTADC IVLANITCPS KMLIALNKVD TLPAEDRSNV IAMTERRIRR ALARTTFRNV
PMVPISVVPP DANSIDRFMD AFALSIYVPD RTVAANDPFM FYFDHCFSLR GKGTVVTGTV
ISGKLTQGQT VEIPMAQQTR KVKTIESFHR PVSSIGPGDR AGLCLSQSST YNLDRGLLCE
PGALKMSYGA IVTLKRVPYY KFSIASRLQF QICIGYETIP AKCCFFACEP GKCIQDDKVL
SFKKEGEYAW VHEVHKSNEE AENACHLFAL LRFTRGIYCA LGCNYLGTKL EIEPSSSVCR
IAFYGRTLHL FEDPKFRGTK INWLNVYKPR VRRGVVERIK DEKYATVRDM FRKGCNIEPY
LGCNVTLSTG EVGRLESSFG QGGKVTVFLP GGAKKSTINT VSKQSKNLDD DLVQLSRMAT
TRSLVRWLRL ARTTARPTTM TNRFAPIQPI PRADDVTQRA MHTSGALRRK QKVPKKPTYE
DDDVEVEDNV DDLIDEVDGS AIRCVNVKRP RLDAILKIGC NVSRNSADEV VSEGRVFVNG
RRALKKSLEF FNSFAFVSFL PPQTEAMLST LLPRMLRRLA GRALPTTGNR YIVCCYFSSD
RPKGFGRFYP GAEGERKDEP KKEEKAEQPP EKADSEPNPS DWQGFFKRPP FAQVRTGGPG
GGEQDNRWLL SAVSIGASMA AIVVLYYYMG YREITWKEFV NSYLSKGAVD KLEVVNKKWV
RVYLNPLTAA EPKIPWFNIG SVDSFERLLE NIQKDLNIDA RNYIAVVYKN EVDSNSIISN
LPSILLFLFF LWGMRRFSSF AGMARGGRGA SGGIFGFGAS TARVIKQGDI KVRFKDVAGC
EEAKLEIMEF VNFLKNPQQY MKLGAKIPKG AILTGPPGTG KTMLAKATAG EANVPFITVS
GSEFLEMFVG VGPARVRDMF AMARKKAPCI LFIDEIDAVG RIRGQRFSSG GSEQENTLNQ
LLVEMDGFQT GQANVIVMAA TNRVDMLDKA LLRPGRFDRQ IYVPAPDIKG RASIFRVHLS
PLAAEPDKTE LSRKLAALTP GFTGADIANV CNEAALIAAR DLNEKIKMKH FEQAVERVVA
GMEKKSQVLQ LEEKTTVAYH EAGHAVTGWF LEHADPLLKV SIIPRGKGLG YAQYLPKEQY
LYTKEQLFHR MCMTLGGRAS EEIFFGRIST GAQDDLQKIT QMAYAQVIKF GMSEKVGPLS
FQTPEAGDVV IDKPYSEQTA QLIDQEVRTI VSNALQFTRK MVEEHREGVE KVVLLLNDFQ
VVYGVFFCWQ VAKRLLEREV LAREDLIELL GQRPFPEKHT YEQFVEGTGG LDDDVSVPEG
LKHWNEPKQE QPAAASEKAN AL
//
