ID A0A085MWT5_9BILA Unreviewed; 1840 AA.
AC A0A085MWT5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Intersectin-1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=M514_04751 {ECO:0000313|EMBL:KFD61681.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD61681.1};
RN [1] {ECO:0000313|EMBL:KFD61681.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD61681.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC {ECO:0000256|ARBA:ARBA00006962}.
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DR EMBL; KL367615; KFD61681.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 1.
DR CDD; cd11836; SH3_Intersectin_1; 1.
DR CDD; cd11837; SH3_Intersectin_2; 1.
DR CDD; cd11839; SH3_Intersectin_4; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR007235; Glyco_trans_28_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF04101; Glyco_tran_28_C; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 4.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50002; SH3; 5.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 219..307
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 251..286
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 361..439
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 394..429
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 832..893
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 961..1019
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1077..1135
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1164..1227
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1244..1304
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1343..1521
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..681
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 709..743
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1840 AA; 207163 MW; 67BF8DC7577D29F9 CRC64;
MENERREVVT RRRSSLLTPF EESTALSDKN RPEEDSKRRP ALKPIEDCTR ISDLALHSLF
VTVGTTEFDE LIRAVCSSQS FAILRSKGVT ELVLQIGSGS YEPIAPDIEP YPTVTTFRYR
ESLSSCFQQA DWVISHAGAA SCLEALELGK PLLIVVNETL LDNHQVELAR QLSLDGYATV
AFGQTGRVCL LAGQILWIQL KRNMSATAGG GEWFITPQQW TKYQRQFAAL NPVNGLLSGE
QTKGFLLSSG QPPTILAQIW NLADVTKDGK LDQLEFAIAM FLLEKKHQGV ALPTLLPQSL
LTPVQMTNYP NRLNHPYPAA SYADRWSLAK TTLPQPAIPF KQSSSPYAVQ LANHLARQAA
SKAKYTQMFC GLSEAKSGFL NGKDARTIFC RFGLSNDVLA HIWFLSDLDK DGRLTCEEFC
LAMSYIDSVK DGEKLPPVPL TDVATVGRLR HKSLGSTSVD SAEGSTESVE EFKPRVAKTF
EDKRRENFEK GQAELERRRE QLLKMEQQER EERERKEREE QAKRERERME AERRRQLELE
KELARQREVQ LRQGEEHRKM MEQREAARRE LERQRLVEWE KMRLNELSLQ RQAVVEGVCH
SKQQSKNLTF QVQAFSEKAT DLNSSIAKLR QDVYELTNSF GQMKAERDAN VCSIEEHKNM
VKQLESRLHQ LEFEKRALNE QMLASRTALS LSEPYDQLVN RYNNKLVALE GLKKTLIEID
AEVKEKEKRC AALKAEYENL RQEAQVEWFE NQELIRQAKS RLPRKSSTSA ASKETELQQQ
EQPAVTSVGQ PAKTKDVDEG AWPTGETVSS PKEPSGGSSW VDFKNQPSSN APVTVRYRAL
YEFVARTEDE LSFQPGDIIF VFKNHECEPG WLAGQIKDKV GWFPEAFAEC LDNVAQPELK
QDAQLQQSHP VQKLESINEE SFEREEGTIS SDASRHNAPT VAAPSAGAPA ESRSSVAAST
TGRLFARALY NWKGKTENHL SFSKGSIIRI LEQQEMWWKG ELGNKQGWFP KSYVKINENL
RRSSLTSIGT DKGSSLSNDV RADTIEVGND SAINTKVEET TSTTVESDNT GKDGTIDSCQ
WYVAVYSFIA SEPGDLAFNA GDKILVLQKD SQWWTGRIGD SEGIFPANYV KPLVEEEHAS
SVVSSERTEN ESEENSRCTL TVPVTCEVGE AIAPFKATES NQLPLEPGDI VRIRTKSPAG
WWEGELENGG GKRLGWFPAS YVKVLKASEV QQHNGDSRLA QSGKQCCVVE ACYDYSAAQE
GELTFKQGDL IDVVEKPDND WWLGQLPNGQ RGLFPVNYVK ISEDGIRPES SALVRSSSDL
LYSQQPSFSR VSSSLSWTSN SRKRNMHFQE LLRSESNYVE DLIMVRDVFQ RPMIREKSLS
RQDSDAIFVN WSSLIKVSRQ FIAQLNEWGD DGVGKAMLYM LPQFDAFATF GKHLRSALDY
LDHRLTTSVP FRAAHARCCS HSKARGLPLN YFLLIPMTRF TKYPLVLKEL IKYTPPSHPD
FGNLEQAIFD LRALCDDVNR LASQAENLHM LHWCQCHIRC DSLLPTMVFN ASTNRLGPRK
FIHSGILYKA KSNRLLVGFL FNDFLMLTTP DEPIGDPSTF KVHANCESIF SLYKKPLMLS
HATLNVANDA GDDSSSCQFS LSTEESTVHL KAISGNARML WKKQLDAAIN QVALVTVYPL
FNLHNFFLSQ ARQRSVTIVK YQPTFKHAMG RISVEVQCVR NLPIPSDCRA YPVLVELKVG
DSKQLLAVDP DRKESPLCSA QFLFESLRCV LSVQFVVELQ FSPSIIVGET SISIEDMIRL
AGPDRNPVVK QLSLTGHLIS ENMAATAIVL IKFSVNVFNE
//
