ID A0A085MXB5_9BILA Unreviewed; 995 AA.
AC A0A085MXB5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 29.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=M514_12119 {ECO:0000313|EMBL:KFD61861.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD61861.1};
RN [1] {ECO:0000313|EMBL:KFD61861.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD61861.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; KL367608; KFD61861.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085MXB5; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 475..492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 528..554
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 644..665
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 685..708
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 729..748
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 768..801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 829..847
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 859..881
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 901..918
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 924..943
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 138..371
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 411..907
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 218..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 111405 MW; 72426FAA5A57DA04 CRC64;
MSNCRSLPTL ETQEKKTAFC RHDSWSELYH PANMSGFVRK ISTNFAASVP RKDTIMSTKG
DFLVDPFVAG QTIHAGQSGE ALAERIRSLI ESELIPEEEG AEFHPLFCEL LSLTENPEQG
ERYFWAEKSR WIKYEETVEE GERWSKPHIS LLTMDNLLLL KSALKNCDSN FGFQVSGYVE
LIEYITESWS KQFDISKTEV KSAKAALLAR KRHFKKPKLR MSDMTSPDSS GNIVEQEEGE
SQKNSAKAAA KQAHRTLLRK LPKDTEGAAV LIGYIDGISR PLAHFVRLKT ALLIDDLLEL
PIPTRFVFVL LLPIDHAEQD ALSIGACFGA LLVDEVFSKV CYKANDCKDL TYAVDEFISQ
SIIIPAGKWN PSSRLEPADN AVPVKRTIGR IRRQILAQTP PTKKTFQRTG RIFGGLIDDL
KTKAPWYVSD FTDGLRGRLT QTIAAAIFLF FANISKIITF GGVMDHVLKK QIGTIENVLA
GGVCGIIYAL FAGQPLCVLS ATGPCLVFEA MMFSFCENQN WDFLCARFWV GFWTSVVLLI
FVAFDASVMV SWITRFTEEA FASLISLIFL VKALEEMFAI TETNPVLPKI TVSLDDDKFF
KANASQSARI ARSLSSESHN FTISECYELG GRVQDDACII EPNVYLFSII MIILTAAIAF
AIKWFRNSSF FSSRVRNVIA DFNVTIAIAV MAVLNACLNI HAPCLSVPDR FVPTSGRSWF
VNPLSIDPWW LSLVAILPAL FFSILILMDQ NITSVIINRP DNKLQKGFGY HLDLTVISLL
MIVCSLLGIP FYVAATVISL MHLESLRIMS EIAAPGEKPA FLGIKEQRVT ALIAHILIGL
AVFLTPVMKL VPVPALLGIF IYMGIVSLIG QQFMERVLII FMPAKHQPDY PWLRMVPLRK
IHIFTAVQIL SFVLLAIVEE VKIVSMLFPL MLLVLICIRR FVLPLLFSNK ELKVLDDELP
SWNEVMKPKQ RPRKSKALAL SDTAQKVQLL PNSEV
//
