ID A0A085MYA5_9BILA Unreviewed; 1299 AA.
AC A0A085MYA5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Coronin {ECO:0000256|RuleBase:RU280818};
GN ORFNames=M514_12832 {ECO:0000313|EMBL:KFD62201.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD62201.1};
RN [1] {ECO:0000313|EMBL:KFD62201.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD62201.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SIMILARITY: Belongs to the WD repeat coronin family.
CC {ECO:0000256|RuleBase:RU280818}.
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DR EMBL; KL367600; KFD62201.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10856; CORONIN; 1.
DR PANTHER; PTHR10856:SF43; CORONIN; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR Pfam; PF00400; WD40; 3.
DR Pfam; PF16300; WD40_4; 1.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM01167; DUF1900; 1.
DR SMART; SM00320; WD40; 3.
DR SMART; SM00734; ZnF_Rad18; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50173; UMUC; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280818};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 85..324
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REPEAT 613..655
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 663..705
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 706..747
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 951..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..81
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1073..1100
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 967..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 147005 MW; B3680BF58561F6BD CRC64;
MQFNDCKAGM QGLDREKIGA KIDEWSKGSR FYDHQMKRRE RIERRVQNMR TQLRFLSEQQ
LKAAEAKMDK CAEDFESMRD LSRTVFHVDM DAFFAAVEMR DDPKLRSVPM AVGSTSMLST
SNYLARKFGV RAAMPGFIGR KLCPDLVIVP CNFSKYKTIS NQVEAILQEY DSTLVMGSLD
EAYLDLTEFI ASRKQLEHPV KHTRVRYGGP CSCMSPSFAL PTILPENEYN IVVETCDICG
HSRLRLVDEV TFGNTAQEIA QEIRFRVEQA TQLTCSIGIA CNGMLAKVCS DINKPNGQFY
LEFDRTVIID FVQNLPIRKI CGIGPVTEAI LRGLDITTCK HLFEKRAQLY ILFSQRSSAY
FLRVSLGIDG WAFEKDEEYT RKSIGVERTF NELNTREQLL EMCCDLCDTV ARSAVKRNLK
GRTITVKLKT IAFDVMTRAY TAKYYTNDAD EMFAIASEIL LNEIRAISPK PLRLRLMECS
GTYPDSSQQA SIYSEFTCPI CKLIIKGIDL RAINHHVDVC LNVSAIEELR TGSVAIVSTM
QFVRQSKFRH VYCKSVRRES CVEDVRITKI AWDSLFCTVN PKFLAVIVEG SGGPFMVIPI
GKTGRIEKDH PLVDAHKAPC LEVAWCPFND NVIASCSEDC TAKIWHIPDG GLQKSLKTPL
VELLAHQKRV TAILWHPTAN NVLLTAGADA KIFLWNVSTG EALIEISGHP DLIWSIDFNY
NGSKLLTTCK DKMIRVIDPR SGRILQQGTG HEGVKPQRAI FLNDGRIFST GFTRRSERMY
ALRSEQALEE PIIQEELDTS NGVLYPLYDR DTGLIYLCGR GDSNIRYYEV NNDPPFVHYI
NTYTSPEPQR GIGFMPKRGL NVDENEIARI YKCTNKGLVE ILQFFVPRKS EMFQEDLYPD
TAGTVPAISA EEWLNGKDAD PILVPLRSDK RQNEHPGEPK KQAVRRANIL AEVPPTEPAS
AATVSKRRSV AAASQETAPK ADSSLTTVTD VLAQRRRESV PMKSELFADV DTGIVQLRHH
ESRDEYGSGR QGAGAVTESG FFSAAMASQR PRSEFMPKRA PEHNHLNDPN ERIEELTLEV
NRLKRIVRQL ASRLKTVEQQ LFQQFTPRDQ WDSNCLFKSV ALFSMIDALK VVKQQEKHER
RIKATYQRNP IKISACKRSA IITEMLTGFL LIVSALLSNA EVSGTRVISD LSEVVGYIPP
HVTNIQESIE LTIPPPKPGS IRPYARDECT LWKCDLQHKA WKKTNVSENY ELFMSCLDKC
EIELILQWTS RWIREISGEQ KIGQDGKKSK KNSKSGWFK
//
