ID A0A085NAT5_9BILA Unreviewed; 2640 AA.
AC A0A085NAT5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
GN ORFNames=M514_01577 {ECO:0000313|EMBL:KFD66581.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD66581.1};
RN [1] {ECO:0000313|EMBL:KFD66581.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD66581.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGU family.
CC {ECO:0000256|ARBA:ARBA00010026}.
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DR EMBL; KL367523; KFD66581.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:InterPro.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009600; PIG-U.
DR PANTHER; PTHR13121; GPI TRANSAMIDASE COMPONENT PIG-U; 1.
DR PANTHER; PTHR13121:SF0; PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF06728; PIG-U; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1190..1208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1215..1236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1242..1260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1317..1338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1768..1786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1991..2013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2033..2059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2071..2094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2100..2123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2195..2220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1377..1617
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2302..2564
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 828..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2640 AA; 300367 MW; 5AC60FFA3C455355 CRC64;
MLSSNSHIFS RLFRSESLYF VLAFALRAFL SFVGLGDRLE NRVEIATPFN SWKRVKEGVA
LKNAGISPYE GDTVHCNPIL LLFFETLTRR GIVITQVVFF MADLLAAHFL AKAVVAFHRE
ELAKEKEAKS SYAKDVEPLL LEGSDSRRIG RIVLITYLFN PLAVLSSVAM TLTTFGNFNI
ILALFLSISG SKKLCFVVLA FATVTDVYPA VFIVPMLVSM YTEGMLAVAL SGLTYIFSTI
AFIYFSYIAA SDWSFLSNTF GSLFMLSDLT PNIGLFWYYF AETFEHYRLF FLCIFHLSFL
TYALPISFCL RDDRFTACFF MLFVIALFKS YPSVCDAAVY SSLLPAFSHL FYYVRYGLPV
TCTIVTCSVL SSIMWHLWIE QGSANANFFF AVTLAYAVAQ IFLMTGLFYA YVRRRFHLKH
ALWSDSLNDR LDRCGILSLP VYSYNIRENR YEFLAKIVLS CHGFQCLILN LQPSIKNTEP
FQTLLRAPAN MMGFLVDPCR QFSVLTFKNL LQKIRKQRRL IFELAFAPLI LLGLLNLINV
NRAKQFPQCT FSPISISSTD PLDILSDFFC LSKVSCAENV DHEVLQSRED DRPLSLIEIR
QAFEMDNELY TNFSTVITEA SEILYYISKV SPGRINFDGV LLSKLLNVNS VAVTRAAQLL
DIPGGVASCF MNSTLKSNFF AKILRRMVMV ADFSLVRHIE ETLCSGSDSV DEYLAWNCTH
LTAERVRRYM CSGTLEEQLG DMLLKRLDSS IMVDIVAKNF TGLQVTSDGV KRVFKSYITM
RKILKKSKTR RLFVQLFKTI STATYSTEEP NERFKRFTDS FFCGRNPQKK KLPSDESAKK
LKEASHYSST KSRSKSRSAH QFQTWEKIFA SSIEDLQCAK LISKLNFDWA RANKMIKFLR
GQVFLIPDNP FIHEILSKIN RRLETLGAAR SHLEFWLDAF KLLLLPQHSP LEDVVVKLGI
MLSNLNKSLD GLPDVEPVLS WLHQERKDLY TEVYVWNTLQ NILKCWEVSR FRVQEVTDKG
KDRAGLLDNL NLLLAKVHFE LTENPIGWLN IKYGIDMSKT YAGEQRTRRL RGVPLPVRNP
STYLEHMELK NLIDYALMEI GISDVQVEGR RVYAHPWAVE QRSRPQLSRN VKEIIVTVLF
VISLFAHNLG VYREVGYERE QHSREFLSYL GVSQVAYFAA WIASSLIWEL ASLCTVYFAL
SQYGILTYSN SACLAVLLFA YCISLCCMCC LVVTLLNGVQ LSAVSLFLLD IVFLLPWLIC
QLATRDVTKY VRVISLTLPQ STMAWIVKEV LDLESRASGI QWTVFESNAV HSEETGILFH
MLILLVQAFV YFLLTLYFDS ILPDSYGLSK SWNFPFSLLS DCWKRSEEEV PVRGVAVKFT
DVSTNGSDDV NRASSNNTLN FQICENSLFG ILDEGMLTGR TLMSAAMLLL SGLLKPACGK
VSWFHSSKRE TVRIDPKSSV LFCPHYSILF YDLSFEENFC IYTSLLGLCC DNKKDELLLN
ELLARLKMKD RMKLYSQELS LGEQKVLSVL IALQLGRRIL VLDNPGLEAC FKLRLKLWTL
LSQKTKHTTI ILSTTFPDVV DRFADGVAVV SGSNVQFFQT VSEFRDWLNI GYHICLSGFV
ADLPKNEPAW ISVKKNFLRV LDRCFHQKEL CKRTDAYVEF VVPRCSFDKL AAFCNYFEKK
RSSIGCLRME IFELRTKEAL RNGLPNVRTL KAARNNRSLC DEVEMELLKP DAVPDVSYLK
NKRPSTRAQF AAIWYRRFIL FYRGHRRLFL MLLYPLLSIG IVLYLLEGME HKHKVAVSTE
LGRTTVILRY TNITNLPYKT AHGVRMKVGV LNDDSSQRKN VNRSSRRDLR NAAAEGAIAN
DALSSKTKGC TYMTHMNGEL SKLAIGETSW RRKLSSIFQR LNVTFIKLPQ KEGRGDEDVE
LKPLLSYTVR YKHAMPELFQ KCINDINNDF VNVVCRKHGR VHKPVWGTEK ATAKLRSITE
RTAWRIALQD LCLAMVWCQG LCFICLCCCR VVMEDTTTGK KKLLFISSLS PPVYWLSNFI
FDLIIYIGTV LLNGCFLFSS GLFIYKNSAG LLFNFIILTQ AFGACMIALI YLMAKVLPSK
LVGGVTVFLF FIFTGLVPAG FMLSAEYWQF LNAEELFYLG QPFDSDFPKE IGQIALLALP
PYGLITALME LQVMARSLNE EDNDCTTELF RVPNLLWYTL LILSVETLLF IITGILGDLY
SNRQLTWKKK SEPSEEAADV EQGKPTDAKE VRPPIEAQKL CKASLMTYNV CFYQNKRTSD
VQVTIILGYC STGRTTDCLC NTKVQTTTKI HHYWDFKCEP DDGCPVNFKR KTVIENVSIC
LPYGVCVGVF GHQRSGKSTL CQLLAAMETA TSGKVTFHSI SDTNPALDQI GYIPRESQLD
ADLTVMDTLT FYAKVRCIQE SVCTKIVCDI LCAFDLTSLM NRRVEFISEA EKKRLSLAVA
FVGGPSVVIL DEPTKYLTFQ ECRRLYQAIS SMLDNRTTIL IASEKFAFRF NLSGRKINGT
LLSTDFLRCV CRDINVINNG QIAEFGSLTN QEWKYGPAYI VEIKLLRREQ ISWLTKFIKE
RMPHAELCVY STTIVAKIPQ LSSDASPILI MQLADSISRS FAIDRISIYL NSLNDILEAS
//