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Database: UniProt
Entry: A0A085NKH0_9BILA
LinkDB: A0A085NKH0_9BILA
Original site: A0A085NKH0_9BILA 
ID   A0A085NKH0_9BILA        Unreviewed;      2635 AA.
AC   A0A085NKH0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 14.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=M514_06768 {ECO:0000313|EMBL:KFD69966.1};
OS   Trichuris suis (pig whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichuridae; Trichuris.
OX   NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD69966.1, ECO:0000313|Proteomes:UP000030758};
RN   [1] {ECO:0000313|EMBL:KFD69966.1, ECO:0000313|Proteomes:UP000030758}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD69966.1};
RX   PubMed=24929829; DOI=10.1038/ng.3012;
RA   Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA   Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA   Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT   "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL   Nat. Genet. 46:701-706(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KL367491; KFD69966.1; -; Genomic_DNA.
DR   Proteomes; UP000030758; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1240; -; 1.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   SUPFAM; SSF53254; SSF53254; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030758};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030758};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    277    298       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    310    331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    370    389       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    451    472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    484    506       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    612    633       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    645    668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    735    755       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    813    834       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    995   1013       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1033   1054       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1112   1142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1237   1264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1318   1336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1348   1368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1417   1435       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1481   1501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1568   1592       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1747   1781       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2635 AA;  299142 MW;  4260736AC003C055 CRC64;
     MPMDGKASKA PFNGFLSVNF ARRTVGKHFG PIWATLIDRI KYIALLYCGY ALQRPACGPF
     RRGGLNGDLP KRCQGKGKNG SCFALVERPF STSAYPVPCL FPKGPSFCRQ NDLGAWRAGG
     KLGILLFLSM ASGDVADFEY AKSSGNEDGA LGQSISGNEA VALLQNAEQR PSRADLWQQT
     LQAAVAASSQ GNGGAKKRQQ QRKMPRSVQQ ERPERSLMCL GLKNPVRKLC IGIVEWKPFE
     WLILCMICAN CIALAVYQPY PAHDSDRKNA VLEQVEYIFI IVFTIECIMK VIANGFLFHP
     GAYLRNGWNL LDFLIVVIGL VSTALSTLNI HGFDVKALRA FRVLRPLRLV SGVPSLQVVL
     NSILRAMVPL FHIALLVLFV IIIYAIIGLE LFCGKLHKAC VDFTTGDLVA DPSPCGESET
     SFHCDRSKNL ICTENHTWPG PNDGITNFDN FGLAMLTVFQ CISLEGWTDV MYWVNDSVGR
     EWPWVYFITL VILGSFFVLN LVLGVLSGEF SKEREKARAR GLFQKFREKQ QLDDDTKGYL
     DWITQAEDID MVGEEEEAEA ADREEFAEGE TGEEVLKEEF QRQNWFSKRL KRLKKLNRRC
     RRCCRRIVKC QAFYWLVIVL VFLNTMVLTS EHYGQPEWLD RFQDVANLCF VILFTLEMFL
     KMYSLGFVNY FVALFNRFDC FVVVSSIVEF ALTSAGLMKP LGVSVLRSAR LLRIFKVTRY
     WNSLRNLVAS LLNSLRSIAS LLLLLFLFIV IFALLGMQVF GGKFNLINPH AVKPRANFDT
     VVQALLTVFQ ILTGEDWNAV MYNGIEAFGG VHSIGVIVCI YFIVLFICGN YILLNVFLAI
     AVDNLADAES LTAAEKEDDE NRRAASGEDQ IDESLEKVQA DNAIFMDSFT ATETEKLPID
     KSGKRARSSV CVRSLIHNKD GVPLDANAVT NGVSAEEPAE SDEGEQEFPV TARPCRLSDL
     NIPKKTKPIP KASSLFIFSS TNPIRLLCNR IINHSYFTNA VLVCILVSSA MLAAEDPLQA
     RSFRNQILNY FDYFFTTVFT IEISLKVLTY GLILHKGSFC RNAFNLLDVL VVGVSLTSFG
     LESGAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVIVA LKTIGNIMLV TFMLEFMFAI
     IGVQIFKGTF FRCSDPSLIT PQECKGTFIE FEGGDISKPE VRIREWTNYD FNFDNVQNAM
     VALFVVSTFE GWPDLLHVAM DSSDENIGPQ YNARISVALF FIAFIVVIAF FMMNIFVGFV
     IVTFQNEGER EYENCELDKN QRKCIEFALT AKPQRRYIPK NRMQYKIWWF VTSQPFEYAI
     FIIIMLNTLI LGMKHYKSST AFDETLDILN LFFTSVFALE FVCKVFALTF KHHAMTRTFD
     EVLDTLNLVF TGIFAMEFVL KVMAFRCKNY FGDAWNVFDF IIVLGSFIDI IYGKVSPGSN
     IISINFFRLF RVMRLVKLLS RGEGIRTLLW TFMKSFQALP YVALLIVLLF FIYAVIGMQV
     FGKIAMSPGT EIHRNNNFQT FPAAVLVLFR SATGEAWQKI MLSCANTPTA ICDPESDDSG
     QPCGNDFAYP YFISFFMLCS FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFVRLWSEY
     DPDAKGRIKH LDVVTLLRKI SPPLGFGKLC PHRLACKRLV SMNMPLNSDG TVCFNSTLFA
     LVRTNLKIYT EEKPFLFLKK SDKAESQSLV SSNIEEANEQ LRAVIKRIWK RTPQKLLDEV
     VPPSGRDDEI TVGKFYATYL IQDYFRRFKK RKEMEQKESH SQGNLTMSLQ AGLRTLHEIG
     PEIKRAISGN LETDWSKEFE EPQHRRDHSL FGTLVQALQA HYKPFIESGT TTNNNVYSKV
     NGDLKLANSG VGTMNDLKVP PVRSDREKTS ELESDESGAK RRPRRGSSFF SSFRLRRPSR
     MSPPHVSPTE SPYEHEYDDA EVAARPQMPA HYRKPESKPY PLNVVRPPMP WMEESRIRSN
     RGPKRLHFSN AVILDESDPE PVGRRPSNIV DLNASSEEES RSPSSPPEEF REEVGYGDRL
     DYGTWRPAPN GQGVRFPSSS SLPWPRPGPS TPKQRSYADV LVEQVLTNRG LGRYTDPHLI
     RTAQLEIAEA YNMTEEQLQS AARSIVQQSP KYFEHLGGQK PSDIKDFNQY SQSALFKPRS
     VNEDDMPGGM HVFMSAVYVE TLTVEYVDNI RSPQRYVPDF KMPLYDCCDS SHSSVQQSFK
     EEIDEAIMNF IYVVEQLLSC GVVRCAERRM SNFIQRDFSL WRSSIRSVSS FLPFWLRHIR
     QAAIQFCFNC CKQKRMQLPP MVCSKFLTMK WALDSLSVLV SLPFLIYSQY GCNLSYTFGL
     YVRDTYGRLV HPSYIASEIY VRSLDKDASI STALCFLQGL YVCLQCNPAC LRTGIPVHTE
     SMDRDFLLNC RANCPVYKSL YNRQSGEAVK QLRKEYNSVF EKLKPFQTNK TVPVSFRRLQ
     DVHATISSRV NLGLRLQLQL TNRYPGGQSG FIGAVRRLDN LTTYLEYNTL QKARLKAGYL
     IGTILNNMEM KVKDVPEASR KLFHYVTERR CLVGFLAALN ISARIPEQDF AIGFELLPLR
     TEYEVKIFVH DVRTGIRNFV FMPSCGVRVC LLSIFKHVLS SVSLYPLKKR HKACS
//
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