ID   A0A085NSD4_9BILA        Unreviewed;      1411 AA.
AC   A0A085NSD4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=separase {ECO:0000256|ARBA:ARBA00012489};
DE            EC=3.4.22.49 {ECO:0000256|ARBA:ARBA00012489};
GN   ORFNames=M514_01696 {ECO:0000313|EMBL:KFD72380.1};
OS   Trichuris suis (pig whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD72380.1};
RN   [1] {ECO:0000313|EMBL:KFD72380.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD72380.1};
RX   PubMed=24929829; DOI=10.1038/ng.3012;
RA   Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA   Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA   Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT   "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL   Nat. Genet. 46:701-706(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=All bonds known to be hydrolyzed by this endopeptidase have
CC         arginine in P1 and an acidic residue in P4. P6 is often occupied by
CC         an acidic residue or by a hydroxy-amino-acid residue, the
CC         phosphorylation of which enhances cleavage.; EC=3.4.22.49;
CC         Evidence={ECO:0000256|ARBA:ARBA00000451};
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DR   EMBL; KL367478; KFD72380.1; -; Genomic_DNA.
DR   Proteomes; UP000030758; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0098813; P:nuclear chromosome segregation; IEA:UniProt.
DR   GO; GO:0000280; P:nuclear division; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR005314; Peptidase_C50.
DR   InterPro; IPR030397; SEPARIN_core_dom.
DR   PANTHER; PTHR12792; EXTRA SPINDLE POLES 1-RELATED; 1.
DR   PANTHER; PTHR12792:SF0; SEPARIN; 1.
DR   Pfam; PF03568; Peptidase_C50; 2.
DR   PROSITE; PS51700; SEPARIN; 1.
PE   4: Predicted;
KW   Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          1215..1308
FT                   /note="Peptidase C50"
FT                   /evidence="ECO:0000259|PROSITE:PS51700"
FT   REGION          703..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        703..720
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1411 AA;  158597 MW;  D7029FE621837F6B CRC64;
     MKSFSAKAKH FVDLVGKNRL DEAAELIKGL VDVGFECANS LIISDGTRSR LNWFLFALKN
     CVVKMKENLH IALIVKISDI LEALCEKCDL SGEKDIRATI SKLYQQLCVY ASRVNGPCYS
     VCFSARAVLA SGGRCPSAWK LWISRKHLAA KMAPEKAETN QCALNYSSFQ ECFRKLLKVG
     LMQMEPSSRV ATLRGVLVGK IEVAARSSVA LISFLSNCPS VANSYEFKLL TDVLKSQPLP
     LERAEALIAL SELAARSPSV CSDGSVVSKG DFRASEYLHE AFRVLGDVDE CPSKVHCLCK
     ASLLKFLQNL RTLIASDFAT PNPVVSCMKT NYANRFCSSS KFDVISGVDK FGPLMTLLKE
     TIQLCQNSLI PRYASAAANE RERITELVHN LAAVSLLYGN LTEAIRMLFW LFTTVESVEV
     YQQLIVAFLV ADAPVFCSAF IDNFEGKVRT ESKLEESYVQ RLRLFGGLCS RDVSAFLLLS
     SIVAKLKDFQ VLHLYGNTVL FCLQLNDNQV SLFKEALDMV SKCKLEEPTD LLSFRNKALC
     YLSLHCCARR QCMAENIKLL RSSSPGMTSV LLSLKHMRSI MKHHLGETTD IQHFSANCWI
     DIALYLWLNK ELARAYEQAG LIRFSLAYAD EGLSLSLRFS SPNWLCAFLG LLFEFESRLY
     EPANLRSYLS LGYAFYRFRP RPVAAPLACK TVRKLDFDNM SLEDSSEGTN NEKKSNASDD
     DSASSDSSDL DDFGEFRSFL ENRHKGNCNC WGCSNESFQL AEAYLIGRLI ELSSQRSARK
     ISLLEKVSEQ IAALHQRCLS RLGRALQNLC KEDFFTNCPW SQELDLNAAI RLSILNISLA
     TESVSKLKQR MRKMGSCGDA SVYYRLEMKM FSFTLTGAAE PGDLVFATPR THGNGRNDAM
     TPSERKKRLD IENCIVEQLN MHALSLYSPW YARAHEWLAL NGHKFDNWTI AYHLCEAIAV
     SSRHLALLEH LSGKFDRTPE FPFVFKDVDS VKNCVSNLEK SWTVVTLYLT ADEHAPDLIL
     MRMSSRCDPL IVNLGSAFEV YDAPGELNEL DKKNVRSIKL KDKHKFWAAR FSCDTQMKNF
     LEHLEKKWFN VMTPLLRHVS SETLQCAKEE LIARFSLAPN MAEALVDGWF LLNEKSFRAF
     AKQLVSVKSA QAVVKFLNAT AKPDEYEQVT NEPDLCMLPI HAIESLRQTP VTRVPSLHFL
     AFLVNKWSKI PAVVKDNAFY VLNPTRDLAQ TQQRFETFFK NLHWQGCVGR DPTTDEIRSA
     LKKDLFVYCG HGSGSRYIKI VESHGDRCHA IVLLMGCSSG RLLPPGRLYE PIGSVTYYQL
     AQCPNVVALL WDVTDKDTDR MLHALLSIWL QNSLPLDDNE SGGEMSAHET KEYTNSLLLA
     LNHARKHCKL KFLTGASILS YGLPVVASLT N
//