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Database: UniProt
Entry: A0A086D1Z2_9GAMM
LinkDB: A0A086D1Z2_9GAMM
Original site: A0A086D1Z2_9GAMM 
ID   A0A086D1Z2_9GAMM        Unreviewed;       385 AA.
AC   A0A086D1Z2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 22.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
DE   Flags: Fragment;
GN   ORFNames=GY26_13925 {ECO:0000313|EMBL:KFF48456.1};
OS   Gammaproteobacteria bacterium MFB021.
OC   Bacteria; Proteobacteria; Gammaproteobacteria.
OX   NCBI_TaxID=1492922 {ECO:0000313|EMBL:KFF48456.1, ECO:0000313|Proteomes:UP000028732};
RN   [1] {ECO:0000313|EMBL:KFF48456.1, ECO:0000313|Proteomes:UP000028732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MFB021 {ECO:0000313|EMBL:KFF48456.1,
RC   ECO:0000313|Proteomes:UP000028732};
RA   Joseph T.C., Baby A., Varghese A.M., Reghunathan D., Murugadas V.,
RA   Lalitha K.V.;
RT   "Draft Genome sequence of a halophilic and highly halotolerant unknown
RT   Gammaproteobacteria strain MFB021.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFF48456.1}.
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DR   EMBL; JNVT01000095; KFF48456.1; -; Genomic_DNA.
DR   EnsemblBacteria; KFF48456; KFF48456; GY26_13925.
DR   Proteomes; UP000028732; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028732};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028732}.
FT   DOMAIN       82    298       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      293    362       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFF48456.1}.
SQ   SEQUENCE   385 AA;  43182 MW;  B1CF721D64246484 CRC64;
     SAPSVQTPPR SPEVAEEQAL DQSREREEGG RRGGERQVQV EGSLKHQSGL NPNFTFETFV
     EGKSNQLARA ASRQVSENPG GAYNPLFLYG GVGLGKTHLM HAVGNHLAGL RDNAKVVYLH
     SERFVADMVK ALQLNAINDF KRFYRSVDAL LIDDIQFFAG KERSQEEFFH TFNALLEGGQ
     QMILTSDRYP KEISGVEERL KSRFGWGLTV AIEPPELETR VAILMKKADQ AKVDLPHDAA
     FFIAQKIRSN VRELEGALKK VIADSHFMGK PITQDFIRES LKDLLALQDK QVGIENIQRT
     VAEYYKIKMA DLLSKRRSRS VARPRQVAMA LAKELTNHSL PEIGDAFGGR DHTTVLHACR
     KVVALKEESA DIREDYKNLM RLLTS
//
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