ID A0A086P561_SPHHM Unreviewed; 883 AA.
AC A0A086P561;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:KFG88529.1};
GN ORFNames=BV98_003715 {ECO:0000313|EMBL:KFG88529.1};
OS Sphingobium herbicidovorans (strain ATCC 700291 / DSM 11019 / NBRC 16415 /
OS MH) (Sphingomonas herbicidovorans).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1219045 {ECO:0000313|EMBL:KFG88529.1, ECO:0000313|Proteomes:UP000024284};
RN [1] {ECO:0000313|EMBL:KFG88529.1, ECO:0000313|Proteomes:UP000024284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 16415 {ECO:0000313|EMBL:KFG88529.1,
RC ECO:0000313|Proteomes:UP000024284};
RA Gan H.M., Gan H.Y., Savka M.A.;
RT "Draft genome sequences of Sphingobium herbicidovorans.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFG88529.1}.
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DR EMBL; JFZA02000060; KFG88529.1; -; Genomic_DNA.
DR RefSeq; WP_037468963.1; NZ_JFZA02000060.1.
DR AlphaFoldDB; A0A086P561; -.
DR STRING; 76947.GCA_002080435_01792; -.
DR PATRIC; fig|1219045.3.peg.3773; -.
DR eggNOG; COG0249; Bacteria.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000024284; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000024284}.
FT DOMAIN 707..723
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 633..640
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 883 AA; 94057 MW; 360DA6D3A1158F27 CRC64;
MHSPKDIAAS QPTPMMAQYL TLKAEAQDCL LFYRMGDFFE LFFDDAKAAA ATLDIALTSR
GEHGGAPIPM CGVPVHSADS YLARLIKAGH RVAIAEQTET PAEAKARGGK ALVARAIVRY
VTAGTLTEET LLDTRRDNML VALAQTGGDG AAEIGLAAAD ISTGRFETLT LRAADLPAEL
ARLRPSEIVV PDGLTLDLAD SHPFDRTAFS SNRAETALKR LFGVATLDGF GQFGRAELAA
MGGLVGYLDH AGKGTLPFLA PPVRKASGAH VAIDAATRES LEIIATMNGA RVGSLLGAVD
RTVTGAGARM LAQDLSAPLM DQGRIEARLG LVQLFHDDPL LRDQLRAALR SLPDIGRALG
RVAVGRGSPR DLGQLRDGLN EARLLRERLG RLPDQPPLLR QLLPALDGHG ALVDSLTRAL
VPNPPTETTN GGYIADGYDP ALDELRRMAG DGRRAIAALE AKYREQTGIA SLKIRHNGVL
GYHVEVPARA ADPLMQPESG FTHRQTLAGV VRFNSIDLHE QAGRVAQAGA HALVAEAAHL
EDLIESTLTR KSEIALAADA LSRLDVAAAL AERAAEGGWQ RPHFLPQDGE GPCLEIIGGR
HPVVEDALQR EGQAFVANDC RLGASDRLWL VTGPNMGGKS TFLRQNALIV ILAQAGAYVP
AQSATLTLVD RLFSRVGASD NLARGRSTFM VEMVETAAIL AQATEHSFVI LDEVGRGTST
YDGLALAWAV VEAVHEVNRC RCLFATHYHE LTRLAETLSA LSLHHVRARE WKGDLVLLHE
LAQGPADRSY GLAVARLAGL PPAVLKRAKD VLTRLEAGKA RTGGIAAGLD DLPLFAAVAA
QEEEKVDPLR AALEAIDADA LSPREALEQL YRLKQLAVAG GED
//
