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Database: UniProt
Entry: A0A086TH11_ACRC1
LinkDB: A0A086TH11_ACRC1
Original site: A0A086TH11_ACRC1 
ID   A0A086TH11_ACRC1        Unreviewed;       855 AA.
AC   A0A086TH11;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   11-MAY-2016, entry version 11.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=ACRE_005260 {ECO:0000313|EMBL:KFH48643.1};
OS   Acremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM
OS   23072 / IMI 49137).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales;
OC   Hypocreales incertae sedis; Acremonium.
OX   NCBI_TaxID=857340 {ECO:0000313|EMBL:KFH48643.1, ECO:0000313|Proteomes:UP000029964};
RN   [1] {ECO:0000313|Proteomes:UP000029964}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137
RC   {ECO:0000313|Proteomes:UP000029964};
RX   PubMed=25291769; DOI=10.1128/genomeA.00948-14;
RA   Terfehr D., Dahlmann T.A., Specht T., Zadra I., Kuernsteiner H.,
RA   Kueck U.;
RT   "Genome sequence and annotation of Acremonium chrysogenum, producer of
RT   the beta-lactam antibiotic cephalosporin C.";
RL   Genome Announc. 2:E0094814-E0094814(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFH48643.1}.
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DR   EMBL; JPKY01000002; KFH48643.1; -; Genomic_DNA.
DR   EnsemblFungi; KFH48643; KFH48643; ACRE_005260.
DR   Proteomes; UP000029964; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029964};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029964};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    423    448       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    460    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    567       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    579    605       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    647    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    780    805       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      102    129       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   855 AA;  96764 MW;  2F7CD4ACDF21DDEA CRC64;
     MAENNQDTPF RSAEMELTQL FFSAEQGREV VAALGELGLF MPLDLNKDVN AFQRTFTGEI
     RRLDEVARRL RYFHAQMEKA GIPLRQIDLD TERLASPSTA EIDELAERSQ KLEQRISALN
     DSYETLKKRE GDLTEWRWVL REAGGFFERA SSGNVEEIRH SMDHDDAPLL SDVEQHGATP
     DVGSFSGMGI GFVAGVINRD RIGTFERVLW RALRGNLFMN QAEIPEPLID PTNNEAINKN
     VFVIFAHGKE ILAKIRKISE SMGADIYSVD ENSDLRRDQI HEVNNRLDDV TNVLRNTQAT
     LQAELNQISQ SLSAWTVLIA KEKEVYLTLN KCSNDSARRT LIAEGWCPKN SIPTLRSILH
     DVGNRSGLSQ PPVLATIATN KTPPTYLPTN KFTEGFQTIV NAYGTATYQE VNPLIPMLIT
     FPFLFATMFA DLGHAIIMVV AALAMIYWEK PLKKVKFELF AMLFYGRYIA LAMGVLSMFT
     GLIYNDIFSK SMTFFPSAWE FRKPEGWEEG QAVVATLNDE GYRYPFGLDH AWHGSENDLL
     FTNSLKMKLS IILGWAHMTY SLCFSYVNAR HFRKPADIFG NFIPGMLFFQ CLFGYLVICI
     FYKWSVDWEA ADAQPPGLLN MLIYMMLSPG TLPNGERLFR GQETIQVILL LIAVVQVPIM
     LLLKPLWLNR EHKRARAKGY RGIGEFSRVS ALEDDEDGQA NGRGDSLDGV AMISQNADEE
     HEEFDFSEEM IHQVIHTIEF CLNCVSHTAS YLRLWALSLA HQQLSAVLWS MTMEPALTTI
     GFGGAIMIVV CFGAWFFLTI AILVAMEGTS AMLHSLRLAW VESFSKFAQF EGWPFQPFSF
     DAFLEESEDL KEYLA
//
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