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Database: UniProt
Entry: A0A086Z2N7_9BIFI
LinkDB: A0A086Z2N7_9BIFI
Original site: A0A086Z2N7_9BIFI 
ID   A0A086Z2N7_9BIFI        Unreviewed;       580 AA.
AC   A0A086Z2N7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BACT_0001 {ECO:0000313|EMBL:KFI40787.1};
OS   Bifidobacterium actinocoloniiforme DSM 22766.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=1437605 {ECO:0000313|EMBL:KFI40787.1, ECO:0000313|Proteomes:UP000029015};
RN   [1] {ECO:0000313|EMBL:KFI40787.1, ECO:0000313|Proteomes:UP000029015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22766 {ECO:0000313|EMBL:KFI40787.1,
RC   ECO:0000313|Proteomes:UP000029015};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFI40787.1}.
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DR   EMBL; JGYK01000001; KFI40787.1; -; Genomic_DNA.
DR   RefSeq; WP_033504904.1; NZ_JGYK01000001.1.
DR   EnsemblBacteria; KFI40787; KFI40787; BACT_0001.
DR   KEGG; bact:AB656_05770; -.
DR   PATRIC; fig|1437605.7.peg.1192; -.
DR   KO; K02313; -.
DR   Proteomes; UP000029015; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029015};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029015}.
FT   DOMAIN      269    408       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      484    553       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     277    284       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   580 AA;  64149 MW;  41B64B538D1D0C90 CRC64;
     MADDQQDPAQ QARSIWQAAS QALAFSATLT ARDKGWLADI TPEAVFGNTI VLSVSSRAAQ
     TAIQGDLGDT LVKALNLVSG KDMIPAIKIV RDRPAQAEAA PQEAPGPAAP VQASGHDQAK
     HQARQSDRSQ PAAQDEARAQ AERTAQTSDP NPPAQVTQNQ TAQAPQTPES LHRDENPDER
     AHRSAQDSPT EQTPEAEHRS YRQQTFAEQS DSNQQDFTPP TFPMGTNQVE RDPETHLNKS
     ATFATFVPGD SNRFARTVAM AVAEGSGQDF NPLCIYGASG LGKTHLLNAI GNYALVKDPG
     LKVRYVTSEE FTNEFIEALQ DPNRSQGQIA AFNRRYRQVD VLLIDDIQFL GGKDATLEQF
     FHTFNALHDA NKRIVIASDV APKNLKGFEE RLISRFDSGM PVDIKPPDRE TRVAILRMLA
     GTMGIAIPNE VFDLIAERFT ENIRELEGAL TRVTAVASLN NQPVTQTLAE QTLQDYFATD
     VEIKPTDIIS QVAKYFHLTF DDLVGRTRTK NIAMARQIAM YLAREMTSMS LVDIGEVFGG
     RDHTTVMHAY TRISNEMQEK REIYNYVMEL TVRLKQPQND
//
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