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Database: UniProt
Entry: A0A086ZE25_9BIFI
LinkDB: A0A086ZE25_9BIFI
Original site: A0A086ZE25_9BIFI 
ID   A0A086ZE25_9BIFI        Unreviewed;       636 AA.
AC   A0A086ZE25;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 24.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BBOH_1502 {ECO:0000313|EMBL:KFI44775.1};
OS   Bifidobacterium bohemicum DSM 22767.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=1437606 {ECO:0000313|EMBL:KFI44775.1, ECO:0000313|Proteomes:UP000029096};
RN   [1] {ECO:0000313|EMBL:KFI44775.1, ECO:0000313|Proteomes:UP000029096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22767 {ECO:0000313|EMBL:KFI44775.1,
RC   ECO:0000313|Proteomes:UP000029096};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFI44775.1}.
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DR   EMBL; JGYP01000005; KFI44775.1; -; Genomic_DNA.
DR   EnsemblBacteria; KFI44775; KFI44775; BBOH_1502.
DR   Proteomes; UP000029096; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029096};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029096}.
FT   DOMAIN      325    464       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      540    609       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     333    340       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   636 AA;  70440 MW;  5FACC7675FB51D88 CRC64;
     MIRREGTMEA QSSDPKTLAI EIWNDTLGIL RKDVSVTPRG QGWLEDVVPE GVFGPTIVLR
     VSSDATQQAL QSELNPALLR ALKASTGHDM FPAFRVAPNE PTTEPMEPQS ADLRNDNDTM
     SPSISGMAPA TMNPGQAVQT EQRLQESPSS SSFQATNPPQ AATSINHNQQ ADDRSVAISG
     EQQRNSNHEA APTQAVQPTF AGLPSQRDPR FEGLSAAQLR QRREMDGMHQ AIRQNAADFI
     QSQPDANTMH ERALSGNGPT EEFSRQQPAE APSAAEPFDV DQQKFLRDPQ THLNKAATFD
     TFVPGDSNRF ARTVALAVAE GSGKDFNPLC IYGGSGLGKT HLLNAIGNYA LVKDRNLKVR
     YVTSEEFTNE FIEALQNPSQ SQGQIAAFNR RYRQVDVLLI DDIQFLGGKE ATLEQFFHTF
     NALYQANKRI VIASDVAPKN LKGFEARLIS RFESGLTVDV KPPDLETRIA ILRMMASMNH
     TSIPNDVLDL IAERFTENIR ELEGALTRVT AVASLSSQPV SRSLAEQTLQ DFFSSDVEIK
     PTDIIGQVAK YFHLTFDDLV GRARTKNVAL ARQIAMYLAR EMTSMSLVDI GEVFGGRDHT
     TVMHAYTRIS DEMQEKQEIY NYVMELTVRL KQHSDE
//
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