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Database: UniProt
Entry: A0A087ANC4_9BIFI
LinkDB: A0A087ANC4_9BIFI
Original site: A0A087ANC4_9BIFI 
ID   A0A087ANC4_9BIFI        Unreviewed;       530 AA.
AC   A0A087ANC4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BCUN_1438 {ECO:0000313|EMBL:KFI60274.1};
OS   Bifidobacterium cuniculi.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=1688 {ECO:0000313|EMBL:KFI60274.1, ECO:0000313|Proteomes:UP000029067};
RN   [1] {ECO:0000313|EMBL:KFI60274.1, ECO:0000313|Proteomes:UP000029067}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 10738 {ECO:0000313|EMBL:KFI60274.1,
RC   ECO:0000313|Proteomes:UP000029067};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFI60274.1}.
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DR   EMBL; JGYV01000021; KFI60274.1; -; Genomic_DNA.
DR   RefSeq; WP_033517277.1; NZ_JGYV01000021.1.
DR   EnsemblBacteria; KFI60274; KFI60274; BCUN_1438.
DR   Proteomes; UP000029067; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029067};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029067}.
FT   DOMAIN      220    347       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      435    504       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     228    235       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   530 AA;  58590 MW;  3D5572B3166BB1BF CRC64;
     MSAQQADPGA KSAMIWSNAL TLLRSNSALT SRQKGWFEGV LPEAVYGTTI ILAVENTETQ
     HVLQSELNTQ LLQALELANG GVPLFPAFKI LAQETPAEDN ETLPVNVPEQ TPAPRPTQPR
     KPVTATFPAQ PTVSHYDDAV VQTFDDIMPG TTGFPAAETA PATTSPNFVP ASFGSTGKQP
     RIDPATHLNL NDTFDTFVPG DSNRFARTVA LAVAEGSGKN FNPLCIYGGS GLGKTHLLNA
     IGNYALLKQP NTRVLYATSE EFTNEYIDSL RPDKPGSNRI GAFNRKYREV DVLLIDDIQF
     LGGKKETLEQ FFNIFNSLYR AGKRIVIVSD VAPRNLKDFE ERMLSRFQQG LTVDVQPPDL
     ETRIAILRMM AASADARIPN DVLDLIAERF TENIRELEGA LNRVTALASL NGQPVTRALA
     EQTLQDFFSV EVELKPTDII AKVAKYFHLT FDDLVGPGRQ KNITLARQIA MYLTRDLTSM
     SLVNIGQVFG GRDHTTVMHN CKIISDNMQE KQEIYNYVTE LTIQLRQRMD
//
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