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Database: UniProt
Entry: A0A087C1K4_9BIFI
LinkDB: A0A087C1K4_9BIFI
Original site: A0A087C1K4_9BIFI 
ID   A0A087C1K4_9BIFI        Unreviewed;       541 AA.
AC   A0A087C1K4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BMON_1250 {ECO:0000313|EMBL:KFI77154.1};
OS   Bifidobacterium mongoliense DSM 21395.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=1437603 {ECO:0000313|EMBL:KFI77154.1, ECO:0000313|Proteomes:UP000029082};
RN   [1] {ECO:0000313|EMBL:KFI77154.1, ECO:0000313|Proteomes:UP000029082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21395 {ECO:0000313|EMBL:KFI77154.1,
RC   ECO:0000313|Proteomes:UP000029082};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFI77154.1}.
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DR   EMBL; JGZE01000009; KFI77154.1; -; Genomic_DNA.
DR   RefSeq; WP_033513306.1; NZ_JGZE01000009.1.
DR   EnsemblBacteria; KFI77154; KFI77154; BMON_1250.
DR   Proteomes; UP000029082; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029082};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029082}.
FT   DOMAIN      230    369       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      445    514       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     238    245       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   541 AA;  58575 MW;  552DE9D605FABC4B CRC64;
     MAEPQTAPAI QAVQIWSDAL AILQHSSAIT PRAKGWLEGV TPEAVFGTTI VLCVVNGSTQ
     QALQGEMNGP LLTALKMVTG VDMFPAFKIV PPSEPTPTDS VEPPSVRRSQ TTPQQGTGSA
     PVQTSSPSPV PHDVAADHAT ATQGVLPAGT DPIAPSSRPA VDTMTMPSAA PAAAATDEAP
     GAYPVNSHKA ILDPATHLNK NATFDTFVPG DSNRFARTVA LAVAEGSGRD FNPLCIYGGS
     GLGKTHLLNA IGNYALVKTP SVKVRYVTSE EFTNEFIEAL QTPNQSQGQI ADFNRRYREV
     DVLLIDDIQF LGGKEATLEQ FFHTFNSLYQ ANKRIVIASD VAPKNLKGFE ARLISRFESG
     LTVDIKPPDL ETRIAILRMM ASMSHSNIPY DALDLIAERF TENIRELEGA LTRVTAVASL
     SNQPVSRALA EQTLQDFFTT DVEVKPTDII GQVAKYFHLT FDDLVGRART KNVALARQVA
     MYLAREMTSM SLVDIGEVFG GRDHTTVMHA YTRITGEMQE KQEIYNYVME LTVRLKQGST
     D
//
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